The kinetic-segregation model: TCR triggering and beyond.

The kinetic-segregation model: TCR triggering and beyond.

Čájet eará veršuvnnaid (1)

How the T cell receptor engages antigen is known, but not how that 'triggers' intracellular signaling. The first direct support for a mechanism based on the spatial reorganization of signaling proteins, proposed 10 years ago and referred to as the 'kinetic-segregation' model, is...

Bibliográfalaš dieđut
Váldodahkkit:	Davis, S, Van Der Merwe, P
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2006

Geahča maid

The kinetic-segregation model: TCR triggering and beyond
Dahkki: Davis, S, et al.
Almmustuhtton: (2006)

The TCR triggering puzzle.
Dahkki: Van Der Merwe, P
Almmustuhtton: (2001)

TCR triggering: co-receptor-dependent or -independent?
Dahkki: Davis, S, et al.
Almmustuhtton: (2003)

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering
Dahkki: Fenglei Li, et al.
Almmustuhtton: (2024-09-01)

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering
Dahkki: Fenglei Li, et al.
Almmustuhtton: (2024-10-01)

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
Dahkki: Burroughs, N, et al.
Almmustuhtton: (2006)

TCR triggering: Co-receptor-dependent or -independent? [2] (multiple letters)
Dahkki: Davis, S, et al.
Almmustuhtton: (2003)

Mathematical models of TCR initial triggering
Dahkki: Jiawei Shi, et al.
Almmustuhtton: (2024-07-01)

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps
Dahkki: Jason Yi, et al.
Almmustuhtton: (2019-01-01)

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
Dahkki: Yair Razvag, et al.
Almmustuhtton: (2018-02-01)

Lck and the nature of the T cell receptor trigger
Dahkki: Davis, S, et al.
Almmustuhtton: (2011)

Lck and the nature of the T cell receptor trigger.
Dahkki: Davis, S, et al.
Almmustuhtton: (2011)

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism.
Dahkki: Bachmann, M, et al.
Almmustuhtton: (1998)

TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
Dahkki: Limozin, L, et al.
Almmustuhtton: (2019)

The serial engagement model seventeen years after: from TCR triggering to immunotherapy
Dahkki: Salvatore eValitutti, et al.
Almmustuhtton: (2012-08-01)

TCR binding to peptide-MHC stabilizes a flexible recognition interface.
Dahkki: Willcox, B, et al.
Almmustuhtton: (1999)

Taking T cells beyond the diffraction limit.
Dahkki: Van Der Merwe, P, et al.
Almmustuhtton: (2010)

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
Dahkki: Irles, C, et al.
Almmustuhtton: (2003)

Mechanisms for T cell receptor triggering.
Dahkki: Van Der Merwe, P, et al.
Almmustuhtton: (2011)

CDR3 loop flexibility contributes to the degeneracy of TCR recognition.
Dahkki: Reiser, J, et al.
Almmustuhtton: (2003)

TCR signaling: the barrier within.
Dahkki: Dustin, M, et al.
Almmustuhtton: (2014)

On the Control of TCR Phosphorylation.
Dahkki: Fernandes, R, et al.
Almmustuhtton: (2012)

T cell cross-reactivity and conformational changes during TCR engagement.
Dahkki: Lee, J, et al.
Almmustuhtton: (2004)

Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement
Dahkki: Dominik eFilipp, et al.
Almmustuhtton: (2012-06-01)

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells
Dahkki: Patel, A, et al.
Almmustuhtton: (2024)

Molecular mechanisms involved in T cell receptor triggering.
Dahkki: Choudhuri, K, et al.
Almmustuhtton: (2007)

Molecular mechanisms involved in T cell receptor triggering
Dahkki: Choudhuri, K, et al.
Almmustuhtton: (2007)

On the control of TCR phosphorylation
Dahkki: Ricardo eFernandes, et al.
Almmustuhtton: (2012-05-01)

T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.
Dahkki: Brodovitch, A, et al.
Almmustuhtton: (2015)

Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model
Dahkki: Magdalena Migalska, et al.
Almmustuhtton: (2024-01-01)

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
Dahkki: Zhengyu Ma, et al.
Almmustuhtton: (2008-02-01)

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
Dahkki: Geoff P O'Donoghue, et al.
Almmustuhtton: (2013-07-01)

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses
Dahkki: Burroughs, N, et al.
Almmustuhtton: (2011)

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.
Dahkki: van der Merwe, P, et al.
Almmustuhtton: (1993)

Coreceptors and TCR signaling — the strong and the weak of it
Dahkki: Mørch, AM, et al.
Almmustuhtton: (2020)

Coreceptors and TCR Signaling – the Strong and the Weak of It
Dahkki: Alexander M. Mørch, et al.
Almmustuhtton: (2020-10-01)

NetTCR-2.1: Lessons and guidance on how to develop models for TCR specificity predictions
Dahkki: Alessandro Montemurro, et al.
Almmustuhtton: (2022-12-01)

Chromosome Dynamics in Bacteria: Triggering Replication at the Opposite Location and Segregation in the Opposite Direction
Dahkki: Ady B. Meléndez, et al.
Almmustuhtton: (2019-08-01)

Existence beyond death? Encouraging those who face death
Dahkki: Dirk G. van der Merwe
Almmustuhtton: (2020-08-01)

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses.
Dahkki: Nigel J Burroughs, et al.
Almmustuhtton: (2011-08-01)