H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.

H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.

The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli transcription of the Cascade genes (casABCDE) and to some extent the CRISPR array is repressed by heat-stable nucleoid-s...

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Bibliographic Details
Main Authors: Westra, E, Pul, U, Heidrich, N, Jore, M, Lundgren, M, Stratmann, T, Wurm, R, Raine, A, Mescher, M, Van Heereveld, L, Mastop, M, Wagner, E, Schnetz, K, Van Der Oost, J, Wagner, R, Brouns, S
Format: Journal article
Language:English
Published: 2010

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