Discovery of a potent and selective CDKL5/GSK3 chemical probe that is neuroprotective
Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms have not been fully described. We realized that avai...
Main Authors: | Ong, HW, Liang, Y, Richardson, W, Lowry, ER, Wells, CI, Chen, X, Silvestre, M, Dempster, K, Silvaroli, JA, Smith, JL, Wichterle, H, Pabla, NS, Ultanir, SK, Bullock, AN, Drewry, DH, Axtman, AD |
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Format: | Journal article |
Language: | English |
Published: |
American Chemical Society
2023
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