γδ T cells support pancreatic oncogenesis by restraining αβ T cell activation

γδ T cells support pancreatic oncogenesis by restraining αβ T cell activation

Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely activated γδT cell population, which constituted ~40% of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of γδT cells was contingent on diverse chemokine signals. Dele...

书目详细资料
Main Authors:	Daley, D, Zambirinis, C, Seifert, L, Akkad, N, Mohan, N, Werba, G, Barilla, R, Torres-Hernandez, A, Hundeyin, M, Mani, V, Avanzi, A, Tippens, D, Narayanan, R, Jang, J, Newman, E, Pillarisetty, V, Dustin, M, Bar-Sagi, D, Hajdu, C, Miller, G
格式:	Journal article
语言:	English
出版:	Elsevier 2016

相似书籍

The Immunosenescence of αβ & γδ T cells in human blood and skin
由: Xu, Weili
出版: (2019)

341 γδ T cells support pancreatic cancer immunity by enhancing αβ T cell activation
由: Michael Lotze, et al.
出版: (2023-11-01)

γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice.
由: Swati Popat Phalke, et al.
出版: (2019-01-01)

The actin remodeling protein cofilin is crucial for thymic αβ but not γδ T-cell development.
由: Isabel Seeland, et al.
出版: (2018-07-01)

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence
由: Mikiya Ishihara, et al.
出版: (2023-10-01)

γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice
由: Xiaoli Zhang, et al.
出版: (2017-12-01)

Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8<sup>+</sup> αβ T Cells and γδ T Cells
由: Lisa Griesel, et al.
出版: (2024-10-01)

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells
由: Lauren C. Fleischer, et al.
出版: (2020-09-01)

CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis.
由: Melina B Pinheiro, et al.
出版: (2012-01-01)

Immunological Characteristics between αβ TDC and γδ TDC Cells in the Spleen of Breast Cancer-Induced Mice
由: Polyana Barbosa Silva, et al.
出版: (2021-07-01)

Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis
由: Xi-zhi J Guo, et al.
出版: (2016-01-01)

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults
由: Nicola Beucke, et al.
出版: (2021-02-01)

SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling
由: Dongxue Su, et al.
出版: (2023-10-01)

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML
由: Andrew Kent, et al.
出版: (2023-08-01)

The transcriptional landscape of αβ T cell differentiation.
由: Mingueneau, M, et al.
出版: (2013)

Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
由: Patrick A. Sandoz, et al.
出版: (2023-09-01)

CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
由: Hualin Zhang, et al.
出版: (2019-10-01)

Genesis of the αβ T-cell receptor.
由: Thomas Dupic, et al.
出版: (2019-03-01)

Distinct Features of Canine Non-conventional CD4−CD8α− Double-Negative TCRαβ+ vs. TCRγδ+ T Cells
由: Friederike V. Rabiger, et al.
出版: (2019-11-01)

Crosstalk between regulatory T cells and tumor-associated dendritic cells controls antitumor immunity in pancreatic cancer
由: Jang, J, et al.
出版: (2016)

Tumor-Activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via Their Antigen-Presenting Cell-Like Effects
由: Chaoming Mao, et al.
出版: (2014-01-01)

The transcriptional landscape of αβ T cell differentiation
由: Regev, Aviv
出版: (2014)

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation
由: Mingyue Zhang, et al.
出版: (2024-07-01)

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression
由: Muñoz-Ruiz Miguel, et al.
出版: (2013-01-01)

Correction: Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8+ αβ and γδ T Lymphocytes with Different Kinetics
出版: (2014-01-01)

Correction: Chicken CRTAM Binds Nectin-Like 2 Ligand and Is Upregulated on CD8 αβ and γδ T Lymphocytes with Different Kinetics.
由: Maria Zechmann, et al.
出版: (2014-01-01)

Crosstalk between regulatory T cells and tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer
由: Jang, J, et al.
出版: (2017)

γδ T-cells in HIV infection
由: Holt NG, et al.
出版: (2012-09-01)

Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
由: Jan D Haas, et al.
出版: (2011-01-01)

Direct recognition of an intact foreign protein by an αβ T cell receptor
由: Catarina F. Almeida, et al.
出版: (2024-10-01)

Cell cycle dysregulation in pituitary oncogenesis.
由: Muşat, M, et al.
出版: (2004)

The Aging of γδ T Cells
由: Weili Xu, et al.
出版: (2020-05-01)

A Molecular Docking Study Reveals That Short Peptides Induce Conformational Changes in the Structure of Human Tubulin Isotypes αβI, αβII, αβIII and αβIV
由: Oluwakemi Ebenezer, et al.
出版: (2023-02-01)

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways
由: Lena Seifert, et al.
出版: (2015-12-01)

αβ,α'β'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes
由: de Munnik, M, et al.
出版: (2023)

Coreceptors and Their Ligands in Epithelial γδ T Cell Biology
由: Deborah A. Witherden, et al.
出版: (2018-04-01)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
由: Ryunosuke Muro, et al.
出版: (2023-01-01)

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.
由: Jieming Zeng, et al.
出版: (2019-01-01)

The Jekyll and Hyde story of IL17 producing γδT (Tγδ17) cells
由: Rushikesh Sudam Patil, et al.
出版: (2015-02-01)

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy
由: Rebecca E. Burnham, et al.
出版: (2020-11-01)