Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis.

BACKGROUND: Tuberculosis has been associated with genetic variation in host immunity. We hypothesized that single-nucleotide polymorphisms (SNPs) in SIGIRR, a negative regulator of Toll-like receptor/IL-1R signaling, are associated with susceptibility to tuberculosis. METHODS: We used a case-populat...

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Bibliografski detalji
Glavni autori: Horne, D, Randhawa, A, Chau, T, Bang, N, Yen, N, Farrar, J, Dunstan, S, Hawn, T
Format: Journal article
Jezik:English
Izdano: 2012