ER stress and autophagic perturbations lead to elevated extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons

Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder. However, the molecular mechanisms underlying this association are still poorly understood. Here, we hav...

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Dades bibliogràfiques
Autors principals:	Fernandes, H, Hartfield, E, Christian, H, Emmanoulidou, E, Zheng, Y, Booth, H, Bogetofte, H, Lang, C, Ryan, B, Sardi, S, Badger, J, Vowles, J, Evetts, S, Tofaris, G, Vekrellis, K, Talbot, K, Hu, M, James, W, Cowley, S, Wade-Martins, R
Format:	Journal article
Publicat:	Cell Press 2016

ER stress and autophagic perturbations lead to elevated extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons

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