X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

Isopenicillin N synthase (IPNS) catalyzes the unique reaction of L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine (ACV) with dioxygen giving isopenicillin N (IPN), the precursor of all natural penicillins and cephalosporins. X-ray free-electron laser studies including time-resolved crystallography and emis...

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Detalles Bibliográficos
Autores principales: Rabe, P, Kamps, JJAG, Sutherlin, KD, Linyard, JDS, Aller, P, Pham, CC, Makita, H, Clifton, I, McDonough, MA, Leissing, TM, Shutin, D, Lang, PA, Butryn, A, Brem, J, Gul, S, Fuller, FD, Kim, I-S, Cheah, MH, Fransson, T, Bhowmick, A, Young, ID, O'Riordan, L, Brewster, AS, Pettinati, I, Doyle, M, Joti, Y, Owada, S, Tono, K, Batyuk, A, Hunter, MS, Alonso-Mori, R, Bergmann, U, Owen, RL, Sauter, NK, Claridge, TDW, Robinson, CV, Yachandra, VK, Yano, J, Kern, JF, Orville, AM, Schofield, CJ
Formato: Journal article
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021

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