High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test.
BACKGROUND: Depression and posttraumatic stress disorder are both associated with altered function of the hypothalamic--pituitary--adrenal axis. Neuroticism is a strong predisposing factor for depression and probably also a risk factor for posttraumatic stress disorder. This study investigated wheth...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797067429729271808 |
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| author | McCleery, J Goodwin, G |
| author_facet | McCleery, J Goodwin, G |
| author_sort | McCleery, J |
| collection | OXFORD |
| description | BACKGROUND: Depression and posttraumatic stress disorder are both associated with altered function of the hypothalamic--pituitary--adrenal axis. Neuroticism is a strong predisposing factor for depression and probably also a risk factor for posttraumatic stress disorder. This study investigated whether young adults with high and low neuroticism scores show differences in hypothalamic-pituitary-adrenal axis regulation that might relate to their differential vulnerability to psychopathology. METHODS: Neuroticism was measured with the Eysenck Personality Questionnaire in 258 students aged 18--25. Fourteen scoring in each of the upper and lower quartiles of the neuroticism distribution according to gender participated in a combined dexamethasone-corticotropin-releasing hormone test. RESULTS: Low-neuroticism individuals showed a significantly greater cortisol response than high-neuroticism individuals. CONCLUSIONS: The mechanism of this effect remains to be elucidated. High-neuroticism subjects may have a downregulated hypothalamic--pituitary--adrenal axis to prevent harmful overactivation. This is the first demonstration of a difference in hypothalamic--pituitary--adrenal axis regulation associated with neuroticism. |
| first_indexed | 2024-03-06T21:56:09Z |
| format | Journal article |
| id | oxford-uuid:4cfe02ca-fed8-4369-8255-091500e203b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:56:09Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:4cfe02ca-fed8-4369-8255-091500e203b02022-03-26T15:52:47ZHigh and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4cfe02ca-fed8-4369-8255-091500e203b0EnglishSymplectic Elements at Oxford2001McCleery, JGoodwin, GBACKGROUND: Depression and posttraumatic stress disorder are both associated with altered function of the hypothalamic--pituitary--adrenal axis. Neuroticism is a strong predisposing factor for depression and probably also a risk factor for posttraumatic stress disorder. This study investigated whether young adults with high and low neuroticism scores show differences in hypothalamic-pituitary-adrenal axis regulation that might relate to their differential vulnerability to psychopathology. METHODS: Neuroticism was measured with the Eysenck Personality Questionnaire in 258 students aged 18--25. Fourteen scoring in each of the upper and lower quartiles of the neuroticism distribution according to gender participated in a combined dexamethasone-corticotropin-releasing hormone test. RESULTS: Low-neuroticism individuals showed a significantly greater cortisol response than high-neuroticism individuals. CONCLUSIONS: The mechanism of this effect remains to be elucidated. High-neuroticism subjects may have a downregulated hypothalamic--pituitary--adrenal axis to prevent harmful overactivation. This is the first demonstration of a difference in hypothalamic--pituitary--adrenal axis regulation associated with neuroticism. |
| spellingShingle | McCleery, J Goodwin, G High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title | High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title_full | High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title_fullStr | High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title_full_unstemmed | High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title_short | High and low neuroticism predict different cortisol responses to the combined dexamethasone--CRH test. |
| title_sort | high and low neuroticism predict different cortisol responses to the combined dexamethasone crh test |
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