Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
Patients with alcoholism and type 2 diabetes manifest altered metabolism, including elevated aldehyde levels and unusually low asparagine levels. We show that asparagine synthetase B (ASNS), the only human asparagine-forming enzyme, is inhibited by disease-relevant reactive aldehydes, including form...
| मुख्य लेखकों: | , , , , , , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Royal Society of Chemistry
2024
|