Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
Patients with alcoholism and type 2 diabetes manifest altered metabolism, including elevated aldehyde levels and unusually low asparagine levels. We show that asparagine synthetase B (ASNS), the only human asparagine-forming enzyme, is inhibited by disease-relevant reactive aldehydes, including form...
| Main Authors: | , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
Royal Society of Chemistry
2024
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