Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells
There is increasing evidence associating the role of caspases with the regulation of basic cellular functions beyond apoptosis. However, the molecular interplay between these enzymes and the signalling networks active in non-apoptotic cellular scenarios remains largely uncharacterized. Here, we show...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Cold Spring Harbor Laboratory
2019
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| _version_ | 1797067463501807616 |
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| author | Baena-Lopez, LA Galasso, A Iakovleva, D |
| author_facet | Baena-Lopez, LA Galasso, A Iakovleva, D |
| author_sort | Baena-Lopez, LA |
| collection | OXFORD |
| description | There is increasing evidence associating the role of caspases with the regulation of basic cellular functions beyond apoptosis. However, the molecular interplay between these enzymes and the signalling networks active in non-apoptotic cellular scenarios remains largely uncharacterized. Here, we show that transient and non-apoptotic caspase activation facilitates Hedgehog-signalling in Drosophila and human ovarian cells with a somatic origin. Importantly, this novel caspase function controls gene expression, cell proliferation, and differentiation. We also molecularly link this uncovered caspase role with the fine regulation of the Hedgehog-receptor, Patched. Altogether, these findings strikingly suggest that caspase activation can act as a pro-survival factor that promotes the expansion and differentiation of normal healthy cells. These observations have profound implications on our understanding of caspase biology from a cellular, physiological and evolutionary perspective. |
| first_indexed | 2024-03-06T21:56:38Z |
| format | Journal article |
| id | oxford-uuid:4d24bfce-20ff-4948-b044-854d30fffe3d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:56:38Z |
| publishDate | 2019 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | dspace |
| spelling | oxford-uuid:4d24bfce-20ff-4948-b044-854d30fffe3d2022-03-26T15:53:45ZCaspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d24bfce-20ff-4948-b044-854d30fffe3dEnglishSymplectic ElementsCold Spring Harbor Laboratory2019Baena-Lopez, LAGalasso, AIakovleva, DThere is increasing evidence associating the role of caspases with the regulation of basic cellular functions beyond apoptosis. However, the molecular interplay between these enzymes and the signalling networks active in non-apoptotic cellular scenarios remains largely uncharacterized. Here, we show that transient and non-apoptotic caspase activation facilitates Hedgehog-signalling in Drosophila and human ovarian cells with a somatic origin. Importantly, this novel caspase function controls gene expression, cell proliferation, and differentiation. We also molecularly link this uncovered caspase role with the fine regulation of the Hedgehog-receptor, Patched. Altogether, these findings strikingly suggest that caspase activation can act as a pro-survival factor that promotes the expansion and differentiation of normal healthy cells. These observations have profound implications on our understanding of caspase biology from a cellular, physiological and evolutionary perspective. |
| spellingShingle | Baena-Lopez, LA Galasso, A Iakovleva, D Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title | Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title_full | Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title_fullStr | Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title_full_unstemmed | Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title_short | Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| title_sort | caspase dependent activation of hedgehog signalling sustains proliferation and differentiation of ovarian somatic stem cells |
| work_keys_str_mv | AT baenalopezla caspasedependentactivationofhedgehogsignallingsustainsproliferationanddifferentiationofovariansomaticstemcells AT galassoa caspasedependentactivationofhedgehogsignallingsustainsproliferationanddifferentiationofovariansomaticstemcells AT iakovlevad caspasedependentactivationofhedgehogsignallingsustainsproliferationanddifferentiationofovariansomaticstemcells |