Cancers and immune related diseases associated with Down's syndrome: a record linkage study.
OBJECTIVE: To determine the risk of cancers and selected immune related diseases in people with Down's syndrome, relative to risk in other people. DESIGN: Cohort analysis of a linked dataset of abstracts of hospital and death records; results expressed as the ratios of rates of disease in peopl...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 语言: | English |
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2004
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| _version_ | 1826271438400651264 |
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| author | Goldacre, M Wotton, C Seagroatt, V Yeates, D |
| author_facet | Goldacre, M Wotton, C Seagroatt, V Yeates, D |
| author_sort | Goldacre, M |
| collection | OXFORD |
| description | OBJECTIVE: To determine the risk of cancers and selected immune related diseases in people with Down's syndrome, relative to risk in other people. DESIGN: Cohort analysis of a linked dataset of abstracts of hospital and death records; results expressed as the ratios of rates of disease in people with and without Down's syndrome. SETTING: The former Oxford health region, England, 1963-1999. SUBJECTS: Cohort of 1453 people with Down's syndrome and cohort of 460,000 people with other conditions for comparison. MAIN OUTCOMES: As expected, the rate ratio for leukaemia was substantially elevated in people with Down's syndrome: it was 19-fold higher (95% confidence intervals 10.4 to 31.5) than the rate in the comparison cohort. For other cancers combined, excluding leukaemia, the rate ratio was not significantly elevated (1.2; 0.6 to 2.2). The risk of testicular cancer was increased (12.0; 2.5 to 35.6), although this was based on only three cases in the cohort of subjects with Down's syndrome. Significantly elevated risks were found for coeliac disease (4.7; 1.3 to 12.2), acquired hypothyroidism (9.4; 3.4, 20.5), other thyroid disorders, and type 1 diabetes mellitus (2.8; 1.0 to 6.1). A decreased risk was found for asthma (0.4; 0.2 to 0.6). CONCLUSIONS: Our data add to the body of information on the risks of co-morbidity in people with Down's syndrome. The finding on asthma needs to be confirmed or refuted by other studies. |
| first_indexed | 2024-03-06T21:56:40Z |
| format | Journal article |
| id | oxford-uuid:4d2642b2-d645-4d4c-96db-4901b1fae032 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:56:40Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:4d2642b2-d645-4d4c-96db-4901b1fae0322022-03-26T15:53:44ZCancers and immune related diseases associated with Down's syndrome: a record linkage study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d2642b2-d645-4d4c-96db-4901b1fae032EnglishSymplectic Elements at Oxford2004Goldacre, MWotton, CSeagroatt, VYeates, DOBJECTIVE: To determine the risk of cancers and selected immune related diseases in people with Down's syndrome, relative to risk in other people. DESIGN: Cohort analysis of a linked dataset of abstracts of hospital and death records; results expressed as the ratios of rates of disease in people with and without Down's syndrome. SETTING: The former Oxford health region, England, 1963-1999. SUBJECTS: Cohort of 1453 people with Down's syndrome and cohort of 460,000 people with other conditions for comparison. MAIN OUTCOMES: As expected, the rate ratio for leukaemia was substantially elevated in people with Down's syndrome: it was 19-fold higher (95% confidence intervals 10.4 to 31.5) than the rate in the comparison cohort. For other cancers combined, excluding leukaemia, the rate ratio was not significantly elevated (1.2; 0.6 to 2.2). The risk of testicular cancer was increased (12.0; 2.5 to 35.6), although this was based on only three cases in the cohort of subjects with Down's syndrome. Significantly elevated risks were found for coeliac disease (4.7; 1.3 to 12.2), acquired hypothyroidism (9.4; 3.4, 20.5), other thyroid disorders, and type 1 diabetes mellitus (2.8; 1.0 to 6.1). A decreased risk was found for asthma (0.4; 0.2 to 0.6). CONCLUSIONS: Our data add to the body of information on the risks of co-morbidity in people with Down's syndrome. The finding on asthma needs to be confirmed or refuted by other studies. |
| spellingShingle | Goldacre, M Wotton, C Seagroatt, V Yeates, D Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title | Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title_full | Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title_fullStr | Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title_full_unstemmed | Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title_short | Cancers and immune related diseases associated with Down's syndrome: a record linkage study. |
| title_sort | cancers and immune related diseases associated with down s syndrome a record linkage study |
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