[Effect of mutation Arg9lGly on the thermal stability of beta-tropomyosin]

[Effect of mutation Arg9lGly on the thermal stability of beta-tropomyosin]

The mutation Arg91Gly (R91G) in beta-tropomyosin (beta-TM) is known to cause distal arthrogryposis, a severe congenital disorder of muscle tissues. To elucidate how this mutation affects the structural properties of beta-TM, the thermal unfolding of beta-TM carrying mutation Arg91Gly was compared wi...

Полное описание

Библиографические подробности
Главные авторы:	Nevzorov, I, Redwood, C, Levitskiĭ, D
Формат:	Journal article
Язык:	Russian
Опубликовано:	2008

Схожие документы

Effect of mutation Arg91Gly on the thermal stability of β-tropomyosin
по: Nevzorov, I, и др.
Опубликовано: (2008)

Stability of two beta-tropomyosin isoforms: effects of mutation Arg91Gly.
по: Nevzorov, I, и др.
Опубликовано: (2008)

Gly126Arg substitution causes anomalous behaviour of α-skeletal and β-smooth tropomyosins during the ATPase cycle.
по: Rysev, N, и др.
Опубликовано: (2014)

The effect of the arthrogryposis-causing Arg91Gly mutation in beta-skeletal tropomyosin on its position on the thin filament and flexibility during the ATPase cycle
по: Simonyan, A, и др.
Опубликовано: (2013)

Conserved noncanonical residue Gly-126 confers instability to the middle part of the tropomyosin molecule.
по: Nevzorov, I, и др.
Опубликовано: (2011)

Functional investigation of beta-tropomyosin mutations that cause congenital skeletal myopathies
по: Piers, A, и др.
Опубликовано: (2011)

Alpha-tropomyosin mutations in inherited cardiomyopathies.
по: Redwood, C, и др.
Опубликовано: (2013)

The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle
по: Borovikov, Y, и др.
Опубликовано: (2017)

Alteration of beta-tropomyosin function by nernaline myopathy-causing mutations E117K and Q147P
по: Pronina, O, и др.
Опубликовано: (2007)

Mutations in fast skeletal troponin I, troponin T and beta-tropomyosin that cause distal arthrogryposis all enhance thin filament activation
по: Robinson, P, и др.
Опубликовано: (2005)

Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
по: Robinson, P, и др.
Опубликовано: (2007)

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle
по: Borovikov, Y, и др.
Опубликовано: (2011)

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle.
по: Borovikov, Y, и др.
Опубликовано: (2011)

Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy
по: Robinson, P, и др.
Опубликовано: (2003)

Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle.
по: Borovikov, Y, и др.
Опубликовано: (2009)

Mutations in tropomyosin that cause DCM, affect cooperativity of cardiac muscle thin filaments
по: Marston, S, и др.
Опубликовано: (2007)

The E117K mutation in β-tropomyosin disturbs concerted conformational changes of actomyosin in muscle fibers.
по: Karpicheva, O, и др.
Опубликовано: (2014)

Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
по: Bing, W, и др.
Опубликовано: (2000)

Polymorphism of the Beta-1 Gly389Arg receptor in patients with dual atrioventricular nodal physiology
по: Douglas Joel Boris, и др.
Опубликовано: (2020-05-01)

Structure-function relationships of eight mutations in troponin and tropomyosin that cause dilated cardiomyopathy
по: Mirza, M, и др.
Опубликовано: (2004)

Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin filament calcium binding
по: Robinson, P, и др.
Опубликовано: (2007)

alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways.
по: Wernicke, D, и др.
Опубликовано: (2004)

The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.
по: Karpicheva, O, и др.
Опубликовано: (2013)

Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents
по: Ruffles, Tom, и др.
Опубликовано: (2022)

Two DCM mutations in cardiac tropomyosin alter thin filament function by different mechanisms
по: Marston, S, и др.
Опубликовано: (2007)

DYT-TUBB4A: First family from india with the Arg2Gly mutation
по: Divyani Garg, и др.
Опубликовано: (2023-01-01)

[Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies].
по: Borovikov, I, и др.
Опубликовано: (2013)

The Gly103Arg variant in hereditary transthyretin amyloidosis
по: Yihan Xiong, и др.
Опубликовано: (2024-09-01)

Bisphosphonate-functionalized cyclic Arg-Gly-Asp peptidomimetics
по: Carmelo Drago, и др.
Опубликовано: (2012-10-01)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
по: Robinson, P, и др.
Опубликовано: (2007)

Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite
по: Alessandro Pistone, и др.
Опубликовано: (2017-02-01)

Ser49Gly and Arg389Gly polymorphisms of the ADRB1 gene and endurance performance
по: Sawczuk Marek, и др.
Опубликовано: (2012-10-01)

The effect of the dilated cardiomyopathy-causing mutation Glu54Lys of alpha-tropomyosin on actin-myosin interactions during the ATPase cycle.
по: Borovikov, Y, и др.
Опубликовано: (2009)

ADRB2 Arg16Gly polymorphism in the LARGE trial.
по: Manolopoulos, K, и др.
Опубликовано: (2010)

Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide.
по: Bogdan A Danalache, и др.
Опубликовано: (2010-10-01)

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure
по: de Lima Antonio, и др.
Опубликовано: (2009-11-01)

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM
по: Lakdawala, N, и др.
Опубликовано: (2009)

Modulation of the effects of tropomyosin on actin and myosin conformational changes by troponin and Ca2+.
по: Borovikov, Y, и др.
Опубликовано: (2009)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
по: Robinson, P, и др.
Опубликовано: (2007)

Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.
по: Lakdawala, N, и др.
Опубликовано: (2010)