The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria.
Plasmodium falciparum, the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of diseases falls on young children. The mechanism of this immunity is still unclear. However, the...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1797067475442991104 |
|---|---|
| author | Bull, P Marsh, K |
| author_facet | Bull, P Marsh, K |
| author_sort | Bull, P |
| collection | OXFORD |
| description | Plasmodium falciparum, the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of diseases falls on young children. The mechanism of this immunity is still unclear. However, the parasite makes a considerable investment in the insertion of highly polymorphic antigens (parasite-infected-erythrocyte surface antigens, PIESA) on the infected erythrocyte surface, and these antigens are potentially important immune targets. |
| first_indexed | 2024-03-06T21:56:49Z |
| format | Journal article |
| id | oxford-uuid:4d3257e4-b528-4719-8822-b3fd317c8213 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:56:49Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:4d3257e4-b528-4719-8822-b3fd317c82132022-03-26T15:54:03ZThe role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d3257e4-b528-4719-8822-b3fd317c8213EnglishSymplectic Elements at Oxford2002Bull, PMarsh, KPlasmodium falciparum, the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of diseases falls on young children. The mechanism of this immunity is still unclear. However, the parasite makes a considerable investment in the insertion of highly polymorphic antigens (parasite-infected-erythrocyte surface antigens, PIESA) on the infected erythrocyte surface, and these antigens are potentially important immune targets. |
| spellingShingle | Bull, P Marsh, K The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title | The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title_full | The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title_fullStr | The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title_full_unstemmed | The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title_short | The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria. |
| title_sort | role of antibodies to plasmodium falciparum infected erythrocyte surface antigens in naturally acquired immunity to malaria |
| work_keys_str_mv | AT bullp theroleofantibodiestoplasmodiumfalciparuminfectederythrocytesurfaceantigensinnaturallyacquiredimmunitytomalaria AT marshk theroleofantibodiestoplasmodiumfalciparuminfectederythrocytesurfaceantigensinnaturallyacquiredimmunitytomalaria AT bullp roleofantibodiestoplasmodiumfalciparuminfectederythrocytesurfaceantigensinnaturallyacquiredimmunitytomalaria AT marshk roleofantibodiestoplasmodiumfalciparuminfectederythrocytesurfaceantigensinnaturallyacquiredimmunitytomalaria |