Feedback Control and Synthetic Biology: Constraints on Design
Synthetic Biology is an emerging field at the interface of biology and engineering, concerned with the design and implementation of synthetic biological parts, devices and systems. With applications ranging from industrial biosynthesis of chemicals to treatment and prevention of disease, Synthetic B...
| Main Authors: | , |
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| Format: | Journal article |
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Elsevier
2017
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| _version_ | 1797067476054310912 |
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| author | Steel, H Papachristodoulou, A |
| author_facet | Steel, H Papachristodoulou, A |
| author_sort | Steel, H |
| collection | OXFORD |
| description | Synthetic Biology is an emerging field at the interface of biology and engineering, concerned with the design and implementation of synthetic biological parts, devices and systems. With applications ranging from industrial biosynthesis of chemicals to treatment and prevention of disease, Synthetic Biology holds great promise, but faces several challenges due to the uncertainties and noise inherent in biological systems. In this paper we review recent progress in the design and testing of biological control systems that aim to overcome these limitations. We then use classical control theory to derive a number of design constraints for implementation of linear control systems that achieve adaptation and disturbance rejection. Finally, we design a linear system for rejection of ramp-type disturbances, and from this demonstrate how the derived linear system constraints can be embedded in a more realistic non-linear biological context. |
| first_indexed | 2024-03-06T21:56:49Z |
| format | Journal article |
| id | oxford-uuid:4d332b1a-0e3c-4c07-9346-d5add33977b9 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:56:49Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:4d332b1a-0e3c-4c07-9346-d5add33977b92022-03-26T15:54:05ZFeedback Control and Synthetic Biology: Constraints on DesignJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d332b1a-0e3c-4c07-9346-d5add33977b9Symplectic Elements at OxfordElsevier2017Steel, HPapachristodoulou, ASynthetic Biology is an emerging field at the interface of biology and engineering, concerned with the design and implementation of synthetic biological parts, devices and systems. With applications ranging from industrial biosynthesis of chemicals to treatment and prevention of disease, Synthetic Biology holds great promise, but faces several challenges due to the uncertainties and noise inherent in biological systems. In this paper we review recent progress in the design and testing of biological control systems that aim to overcome these limitations. We then use classical control theory to derive a number of design constraints for implementation of linear control systems that achieve adaptation and disturbance rejection. Finally, we design a linear system for rejection of ramp-type disturbances, and from this demonstrate how the derived linear system constraints can be embedded in a more realistic non-linear biological context. |
| spellingShingle | Steel, H Papachristodoulou, A Feedback Control and Synthetic Biology: Constraints on Design |
| title | Feedback Control and Synthetic Biology: Constraints on Design |
| title_full | Feedback Control and Synthetic Biology: Constraints on Design |
| title_fullStr | Feedback Control and Synthetic Biology: Constraints on Design |
| title_full_unstemmed | Feedback Control and Synthetic Biology: Constraints on Design |
| title_short | Feedback Control and Synthetic Biology: Constraints on Design |
| title_sort | feedback control and synthetic biology constraints on design |
| work_keys_str_mv | AT steelh feedbackcontrolandsyntheticbiologyconstraintsondesign AT papachristodouloua feedbackcontrolandsyntheticbiologyconstraintsondesign |