Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease

Εμφάνιση άλλων εκδόσεων (1)

WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, including DNA replication, repair and recombination. In humans, deficiencies in WRN function cause the segmental progeroid Werner syndrome (WS), in which patients show premature onset of many hallmarks of nor...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Bird, J, Jennert-Burston, K, Bachler, M, Mason, P, Lowe, J, Heo, S, Campisi, J, Faragher, R, Cox, L
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2012

Παρόμοια τεκμήρια

Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease.
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Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability
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Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability
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The role of DNA exonucleases in protecting genome stability and their impact on ageing.
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Targeting werner helicase with synthetic lethality in microsatellite instability cancers: Promising therapeutic approaches
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Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
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Synthesis of (+)-camptothecin
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