DNA repair pathways as targets for cancer therapy.
DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pa...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826271456334446592 |
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| author | Helleday, T Petermann, E Lundin, C Hodgson, B Sharma, R |
| author_facet | Helleday, T Petermann, E Lundin, C Hodgson, B Sharma, R |
| author_sort | Helleday, T |
| collection | OXFORD |
| description | DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects. |
| first_indexed | 2024-03-06T21:56:56Z |
| format | Journal article |
| id | oxford-uuid:4d3ab431-934b-41e8-b5d9-9bffaaf3245b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:56:56Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:4d3ab431-934b-41e8-b5d9-9bffaaf3245b2022-03-26T15:54:18ZDNA repair pathways as targets for cancer therapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d3ab431-934b-41e8-b5d9-9bffaaf3245bEnglishSymplectic Elements at Oxford2008Helleday, TPetermann, ELundin, CHodgson, BSharma, RDNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects. |
| spellingShingle | Helleday, T Petermann, E Lundin, C Hodgson, B Sharma, R DNA repair pathways as targets for cancer therapy. |
| title | DNA repair pathways as targets for cancer therapy. |
| title_full | DNA repair pathways as targets for cancer therapy. |
| title_fullStr | DNA repair pathways as targets for cancer therapy. |
| title_full_unstemmed | DNA repair pathways as targets for cancer therapy. |
| title_short | DNA repair pathways as targets for cancer therapy. |
| title_sort | dna repair pathways as targets for cancer therapy |
| work_keys_str_mv | AT helledayt dnarepairpathwaysastargetsforcancertherapy AT petermanne dnarepairpathwaysastargetsforcancertherapy AT lundinc dnarepairpathwaysastargetsforcancertherapy AT hodgsonb dnarepairpathwaysastargetsforcancertherapy AT sharmar dnarepairpathwaysastargetsforcancertherapy |