Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

The envelope spike of HIV-1 employs a 'glycan shield' to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits pr...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit:	Pritchard, L, Spencer, D, Royle, L, Bonomelli, C, Seabright, G, Behrens, A, Kulp, D, Menis, S, Krumm, S, Dunlop, D, Crispin, D, Bowden, T, Scanlan, C, Ward, A, Schief, W, Doores, K, Crispin, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Nature Publishing Group 2015

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

Geahča maid