Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

The envelope spike of HIV-1 employs a 'glycan shield' to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits pr...

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Những tác giả chính: Pritchard, L, Spencer, D, Royle, L, Bonomelli, C, Seabright, G, Behrens, A, Kulp, D, Menis, S, Krumm, S, Dunlop, D, Crispin, D, Bowden, T, Scanlan, C, Ward, A, Schief, W, Doores, K, Crispin, M
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Nature Publishing Group 2015

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