Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies.

The envelope spike of HIV-1 employs a 'glycan shield' to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly neutralizing antibodies (bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits pr...

Full description

Bibliographic Details
Main Authors: Pritchard, L, Spencer, D, Royle, L, Bonomelli, C, Seabright, G, Behrens, A, Kulp, D, Menis, S, Krumm, S, Dunlop, D, Crispin, D, Bowden, T, Scanlan, C, Ward, A, Schief, W, Doores, K, Crispin, M
Format: Journal article
Language:English
Published: Nature Publishing Group 2015

Similar Items

Similar Items