Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine.
In view of the global emergency posed by lack of access to highly active antiretroviral therapy (HAART) and the limitations of current drug regimens, alternative therapeutic strategies are urgently needed. Cellular immune responses elicited by HIV-1 exert some control over virus replication, therefo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797067529180413952 |
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| author | Dorrell, L Yang, H Iversen, A Conlon, C Suttill, A Lancaster, M Dong, T Cebere, I Edwards, A Rowland-Jones, S Hanke, T Mcmichael, A |
| author_facet | Dorrell, L Yang, H Iversen, A Conlon, C Suttill, A Lancaster, M Dong, T Cebere, I Edwards, A Rowland-Jones, S Hanke, T Mcmichael, A |
| author_sort | Dorrell, L |
| collection | OXFORD |
| description | In view of the global emergency posed by lack of access to highly active antiretroviral therapy (HAART) and the limitations of current drug regimens, alternative therapeutic strategies are urgently needed. Cellular immune responses elicited by HIV-1 exert some control over virus replication, therefore the enhancement of HIV-1-specific responses by therapeutic vaccination might lead to viral containment without HAART. We evaluated the safety and immunogenicity, in HIV-1-infected individuals under HAART suppression, of a DNA vaccine, pTHr.HIVA. |
| first_indexed | 2024-03-06T21:57:36Z |
| format | Journal article |
| id | oxford-uuid:4d7067d6-52d5-469c-88c6-5ad81314d753 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:57:36Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:4d7067d6-52d5-469c-88c6-5ad81314d7532022-03-26T15:55:36ZTherapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4d7067d6-52d5-469c-88c6-5ad81314d753EnglishSymplectic Elements at Oxford2005Dorrell, LYang, HIversen, AConlon, CSuttill, ALancaster, MDong, TCebere, IEdwards, ARowland-Jones, SHanke, TMcmichael, AIn view of the global emergency posed by lack of access to highly active antiretroviral therapy (HAART) and the limitations of current drug regimens, alternative therapeutic strategies are urgently needed. Cellular immune responses elicited by HIV-1 exert some control over virus replication, therefore the enhancement of HIV-1-specific responses by therapeutic vaccination might lead to viral containment without HAART. We evaluated the safety and immunogenicity, in HIV-1-infected individuals under HAART suppression, of a DNA vaccine, pTHr.HIVA. |
| spellingShingle | Dorrell, L Yang, H Iversen, A Conlon, C Suttill, A Lancaster, M Dong, T Cebere, I Edwards, A Rowland-Jones, S Hanke, T Mcmichael, A Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title | Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title_full | Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title_fullStr | Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title_full_unstemmed | Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title_short | Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine. |
| title_sort | therapeutic immunization of highly active antiretroviral therapy treated hiv 1 infected patients safety and immunogenicity of an hiv 1 gag poly epitope dna vaccine |
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