Inducing sleep by remote control facilitates memory consolidation in Drosophila.
Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1826271534868594688 |
|---|---|
| author | Donlea, J Thimgan, MS Suzuki, Y Gottschalk, L Shaw, P |
| author_facet | Donlea, J Thimgan, MS Suzuki, Y Gottschalk, L Shaw, P |
| author_sort | Donlea, J |
| collection | OXFORD |
| description | Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training. |
| first_indexed | 2024-03-06T21:58:11Z |
| format | Journal article |
| id | oxford-uuid:4dae4716-4070-449a-9f60-355b453d4f89 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:58:11Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:4dae4716-4070-449a-9f60-355b453d4f892022-03-26T15:56:37ZInducing sleep by remote control facilitates memory consolidation in Drosophila.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4dae4716-4070-449a-9f60-355b453d4f89EnglishSymplectic Elements at Oxford2011Donlea, JThimgan, MSSuzuki, YGottschalk, LShaw, PSleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31°C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training. |
| spellingShingle | Donlea, J Thimgan, MS Suzuki, Y Gottschalk, L Shaw, P Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title_full | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title_fullStr | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title_full_unstemmed | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title_short | Inducing sleep by remote control facilitates memory consolidation in Drosophila. |
| title_sort | inducing sleep by remote control facilitates memory consolidation in drosophila |
| work_keys_str_mv | AT donleaj inducingsleepbyremotecontrolfacilitatesmemoryconsolidationindrosophila AT thimganms inducingsleepbyremotecontrolfacilitatesmemoryconsolidationindrosophila AT suzukiy inducingsleepbyremotecontrolfacilitatesmemoryconsolidationindrosophila AT gottschalkl inducingsleepbyremotecontrolfacilitatesmemoryconsolidationindrosophila AT shawp inducingsleepbyremotecontrolfacilitatesmemoryconsolidationindrosophila |