Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the correspon...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797067591875821568 |
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| author | Hamed, R Mecinović, J Ducho, C Claridge, T Schofield, C |
| author_facet | Hamed, R Mecinović, J Ducho, C Claridge, T Schofield, C |
| author_sort | Hamed, R |
| collection | OXFORD |
| description | The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic beta-lactams by a carbapenem synthetase. |
| first_indexed | 2024-03-06T21:58:32Z |
| format | Journal article |
| id | oxford-uuid:4dc93771-6e56-4589-bfb4-1d5bb949c0f9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:58:32Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:4dc93771-6e56-4589-bfb4-1d5bb949c0f92022-03-26T15:57:24ZCarboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4dc93771-6e56-4589-bfb4-1d5bb949c0f9EnglishSymplectic Elements at Oxford2010Hamed, RMecinović, JDucho, CClaridge, TSchofield, CThe utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic beta-lactams by a carbapenem synthetase. |
| spellingShingle | Hamed, R Mecinović, J Ducho, C Claridge, T Schofield, C Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title | Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title_full | Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title_fullStr | Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title_full_unstemmed | Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title_short | Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. |
| title_sort | carboxymethylproline synthase catalysed syntheses of functionalised n heterocycles |
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