Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.

The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the correspon...

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Detalhes bibliográficos
Main Authors: Hamed, R, Mecinović, J, Ducho, C, Claridge, T, Schofield, C
Formato: Journal article
Idioma:English
Publicado em: 2010