C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR) is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are poorly defined. To inform on these mechanisms we conducted a genome-wide screen for genes that are synthetic lethal wi...
Main Authors: | Sharma, A, Ramlee, MK, Kosmin, J, Wolstenholme, A, Ronson, G, Jones, D, Ebner, D, Shamkhi, N, Sims, D, Gibbs-Seymour, I, Lakin, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2023
|
Similar Items
-
C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
by: Abhishek Bharadwaj Sharma, et al.
Published: (2023-08-01) -
Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
by: Abhishek Bharadwaj Sharma, et al.
Published: (2023-11-01) -
Understanding the role of C16orf72 in the DNA replication stress response
by: Kosmin, J
Published: (2022) -
HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
by: Gibbs-Seymour, I, et al.
Published: (2016) -
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
by: Julie K. Monda, et al.
Published: (2023-05-01)