Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor
The integral membrane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal targeting, binding to β-glucocerebrosidase (β-GCase) and directing it to the lysosome, before dissociating in the late-endosomal/lysosomal compartments. Here we report structural res...
Main Authors: | Zhao, Y, Ren, J, Padilla-Parra, S, Fry, E, Stuart, D |
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Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2014
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