First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine
The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826271648299352064 |
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| author | Sollogoub, M Fox, K Powers, V Brown, T |
| author_facet | Sollogoub, M Fox, K Powers, V Brown, T |
| author_sort | Sollogoub, M |
| collection | OXFORD |
| description | The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides. © 2002 Elsevier Science Ltd. All rights reserved. |
| first_indexed | 2024-03-06T21:59:58Z |
| format | Journal article |
| id | oxford-uuid:4e3ed56b-85be-46da-b347-fb1794a9542c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:59:58Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:4e3ed56b-85be-46da-b347-fb1794a9542c2022-03-26T16:00:07ZFirst synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidineJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e3ed56b-85be-46da-b347-fb1794a9542cEnglishSymplectic Elements at Oxford2002Sollogoub, MFox, KPowers, VBrown, TThe synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides. © 2002 Elsevier Science Ltd. All rights reserved. |
| spellingShingle | Sollogoub, M Fox, K Powers, V Brown, T First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title | First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title_full | First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title_fullStr | First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title_full_unstemmed | First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title_short | First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine |
| title_sort | first synthesis of 1 deazacytidine the c nucleoside analogue of cytidine |
| work_keys_str_mv | AT sollogoubm firstsynthesisof1deazacytidinethecnucleosideanalogueofcytidine AT foxk firstsynthesisof1deazacytidinethecnucleosideanalogueofcytidine AT powersv firstsynthesisof1deazacytidinethecnucleosideanalogueofcytidine AT brownt firstsynthesisof1deazacytidinethecnucleosideanalogueofcytidine |