Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study
<br><strong>Purpose: </strong>To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD).</br> <br><strong>Methods:...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Association for Research in Vision and Ophthalmology
2018
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| _version_ | 1797067697280778240 |
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| author | Müller, PL Pfau, M Möller, PT Nadal, J Schmid, M Lindner, M de Sisternes, L Stöhr, H Weber, BHF Neuhaus, C Herrmann, P Schmitz-Valckenberg, S Holz, FG Fleckenstein, M |
| author_facet | Müller, PL Pfau, M Möller, PT Nadal, J Schmid, M Lindner, M de Sisternes, L Stöhr, H Weber, BHF Neuhaus, C Herrmann, P Schmitz-Valckenberg, S Holz, FG Fleckenstein, M |
| author_sort | Müller, PL |
| collection | OXFORD |
| description | <br><strong>Purpose: </strong>To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD).</br>
<br><strong>Methods: </strong>A total of 43 eyes (23 STGD1 and 20 AMD) of patients with RPE atrophy and 25 eyes of healthy controls without ocular pathology underwent multimodal imaging including optical coherence tomography angiography (OCT-A; PLEX Elite 9000 Swept-Source OCT). Using an exploratory approach, choriocapillaris and deeper choroid OCT-A slabs were evaluated in order to detect differences between STGD1 and AMD. The magnitude of absence-of-flow signal (AFS) was investigated in terms of area-fraction and size-frequency distribution.</br>
<br><strong>Results: </strong>Qualitative and quantitative analysis of areas of RPE atrophy revealed more pronounced rarefaction of the choriocapillaris flow signal in STGD1 as compared to AMD (AFS area fraction: 33.15% ± 6.86% vs. 31.68% ± 8.39%; P = 0.517), while outside RPE atrophy rarefaction was less pronounced in STGD1 (AFS area fraction: 17.41% ± 5.67% vs. 21.59% ± 6.90%; P < 0.001), to the level of nonsignificance compared to controls (13.27% ± 2.99%, P = 0.368). Given this discrepancy, the ratio of the AFS area fraction within/outside of RPE atrophy could be used to differentiate between STGD1 and AMD with 65.0% sensitivity and 92.3% specificity.</br>
<br><strong>Conclusions: </strong>Using OCT-A, comparison of choroidal flow signal within and outside the area of RPE atrophy revealed distinct differences between STGD1 and AMD, potentially implicating a differential role of the choroid in the pathogenesis of RPE atrophy in these two diseases.</br> |
| first_indexed | 2024-03-06T22:00:00Z |
| format | Journal article |
| id | oxford-uuid:4e425bd7-9b3d-4a66-9c41-462d020f8514 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:00:00Z |
| publishDate | 2018 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | oxford-uuid:4e425bd7-9b3d-4a66-9c41-462d020f85142022-03-26T16:00:11ZChoroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography StudyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e425bd7-9b3d-4a66-9c41-462d020f8514EnglishSymplectic ElementsAssociation for Research in Vision and Ophthalmology2018Müller, PLPfau, MMöller, PTNadal, JSchmid, MLindner, Mde Sisternes, LStöhr, HWeber, BHFNeuhaus, CHerrmann, PSchmitz-Valckenberg, SHolz, FGFleckenstein, M<br><strong>Purpose: </strong>To investigate the choroidal blood flow in areas within and adjacent to retinal pigment epithelium (RPE) atrophy secondary to late-onset Stargardt disease (STGD1) and age-related macular degeneration (AMD).</br> <br><strong>Methods: </strong>A total of 43 eyes (23 STGD1 and 20 AMD) of patients with RPE atrophy and 25 eyes of healthy controls without ocular pathology underwent multimodal imaging including optical coherence tomography angiography (OCT-A; PLEX Elite 9000 Swept-Source OCT). Using an exploratory approach, choriocapillaris and deeper choroid OCT-A slabs were evaluated in order to detect differences between STGD1 and AMD. The magnitude of absence-of-flow signal (AFS) was investigated in terms of area-fraction and size-frequency distribution.</br> <br><strong>Results: </strong>Qualitative and quantitative analysis of areas of RPE atrophy revealed more pronounced rarefaction of the choriocapillaris flow signal in STGD1 as compared to AMD (AFS area fraction: 33.15% ± 6.86% vs. 31.68% ± 8.39%; P = 0.517), while outside RPE atrophy rarefaction was less pronounced in STGD1 (AFS area fraction: 17.41% ± 5.67% vs. 21.59% ± 6.90%; P < 0.001), to the level of nonsignificance compared to controls (13.27% ± 2.99%, P = 0.368). Given this discrepancy, the ratio of the AFS area fraction within/outside of RPE atrophy could be used to differentiate between STGD1 and AMD with 65.0% sensitivity and 92.3% specificity.</br> <br><strong>Conclusions: </strong>Using OCT-A, comparison of choroidal flow signal within and outside the area of RPE atrophy revealed distinct differences between STGD1 and AMD, potentially implicating a differential role of the choroid in the pathogenesis of RPE atrophy in these two diseases.</br> |
| spellingShingle | Müller, PL Pfau, M Möller, PT Nadal, J Schmid, M Lindner, M de Sisternes, L Stöhr, H Weber, BHF Neuhaus, C Herrmann, P Schmitz-Valckenberg, S Holz, FG Fleckenstein, M Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title | Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title_full | Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title_fullStr | Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title_full_unstemmed | Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title_short | Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study |
| title_sort | choroidal flow signal in late onset stargardt disease and age related macular degeneration an oct angiography study |
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