A tandem conjugate addition/cyclization protocol for the asymmetric synthesis of 2-aryl-4-aminotetrahydroquinoline-3-carboxylic acid derivatives.

Condensation of tert-butyl (E)-3-(2'-aminophenyl)propenoate with a range of aromatic and heteroaromatic aldehydes gives the corresponding imines as single diastereoisomers (>98% de). Addition of lithium (R)-N-benzyl-N-(alpha-methylbenzyl)amide initiates a tandem conjugate addition/cycliz...

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Príomhchruthaitheoirí: Davies, S, Mujtaba, N, Roberts, P, Smith, A, Thomson, J
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2009