Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have been discovered. For example, 2-(butyloxy)-4-[4-(meth...

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Bibliographic Details
Main Authors: Swarbrick, M, Beswick, P, Gleave, R, Green, R, Bingham, S, Bountra, C, Carter, M, Chambers, L, Chessell, I, Clayton, N, Collins, S, Corfield, J, Hartley, C, Kleanthous, S, Lambeth, P, Lucas, F, Mathews, N, Naylor, A, Page, L, Payne, J, Pegg, N, Price, H, Skidmore, J, Stevens, A, Stocker, R
Format: Journal article
Language:English
Published: 2009

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