Electrophilic fluorocyclization of allyl silanes.
A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorinationcyclization with N-F reagents to give cis- and transsubstituted fluorinat...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826271682165211136 |
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| author | Wilkinson, S Lozano, O Schuler, M Pacheco, M Salmon, R Gouverneur, V |
| author_facet | Wilkinson, S Lozano, O Schuler, M Pacheco, M Salmon, R Gouverneur, V |
| author_sort | Wilkinson, S |
| collection | OXFORD |
| description | A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorinationcyclization with N-F reagents to give cis- and transsubstituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation. © 2009 Wiley-VCH Verlag GmbH and Co. KGaA. |
| first_indexed | 2024-03-06T22:00:31Z |
| format | Journal article |
| id | oxford-uuid:4e6b3f78-860f-4834-8f8e-41e6f54558e5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:00:31Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:4e6b3f78-860f-4834-8f8e-41e6f54558e52022-03-26T16:01:08ZElectrophilic fluorocyclization of allyl silanes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e6b3f78-860f-4834-8f8e-41e6f54558e5EnglishSymplectic Elements at Oxford2009Wilkinson, SLozano, OSchuler, MPacheco, MSalmon, RGouverneur, VA refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorinationcyclization with N-F reagents to give cis- and transsubstituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation. © 2009 Wiley-VCH Verlag GmbH and Co. KGaA. |
| spellingShingle | Wilkinson, S Lozano, O Schuler, M Pacheco, M Salmon, R Gouverneur, V Electrophilic fluorocyclization of allyl silanes. |
| title | Electrophilic fluorocyclization of allyl silanes. |
| title_full | Electrophilic fluorocyclization of allyl silanes. |
| title_fullStr | Electrophilic fluorocyclization of allyl silanes. |
| title_full_unstemmed | Electrophilic fluorocyclization of allyl silanes. |
| title_short | Electrophilic fluorocyclization of allyl silanes. |
| title_sort | electrophilic fluorocyclization of allyl silanes |
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