The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort
<p><strong>Introduction:</strong> The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Frontiers Media
2023
|
_version_ | 1797112139956092928 |
---|---|
author | Singh, SD Oreskovic, T Carr, S Papier, K Conroy, M Senff, JR Chemali, Z Gutierrez-Martinez, L Parodi, L Mayerhofer, E Marini, S Nunley, C Newhouse, A Ouyang, A Brouwers, HB Westover, B Rivier, C Falcone, G Howard, V Howard, G Pikula, A Ibrahim, S Sheth, KN Yechoor, N Lazar, RM Anderson, CD Tanzi, RE Fricchione, G Littlejohns, T Rosand, J |
author_facet | Singh, SD Oreskovic, T Carr, S Papier, K Conroy, M Senff, JR Chemali, Z Gutierrez-Martinez, L Parodi, L Mayerhofer, E Marini, S Nunley, C Newhouse, A Ouyang, A Brouwers, HB Westover, B Rivier, C Falcone, G Howard, V Howard, G Pikula, A Ibrahim, S Sheth, KN Yechoor, N Lazar, RM Anderson, CD Tanzi, RE Fricchione, G Littlejohns, T Rosand, J |
author_sort | Singh, SD |
collection | OXFORD |
description | <p><strong>Introduction:</strong> The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke.</p>
<p><strong>Methods:</strong> The BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline.</p>
<p><strong>Results:</strong> The BCS (median: 12; IQR:11–14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50–59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50–59, and 33% (95%CI, 29-37%) among those aged >59.</p>
<p><strong>Discussion:</strong> The BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide.</p> |
first_indexed | 2024-03-07T08:19:59Z |
format | Journal article |
id | oxford-uuid:4e724d95-9c1f-4030-9694-461a5f6aea0d |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T08:19:59Z |
publishDate | 2023 |
publisher | Frontiers Media |
record_format | dspace |
spelling | oxford-uuid:4e724d95-9c1f-4030-9694-461a5f6aea0d2024-01-22T13:30:26ZThe predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e724d95-9c1f-4030-9694-461a5f6aea0dEnglishSymplectic ElementsFrontiers Media2023Singh, SDOreskovic, TCarr, SPapier, KConroy, MSenff, JRChemali, ZGutierrez-Martinez, LParodi, LMayerhofer, EMarini, SNunley, CNewhouse, AOuyang, ABrouwers, HBWestover, BRivier, CFalcone, GHoward, VHoward, GPikula, AIbrahim, SSheth, KNYechoor, NLazar, RMAnderson, CDTanzi, REFricchione, GLittlejohns, TRosand, J<p><strong>Introduction:</strong> The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke.</p> <p><strong>Methods:</strong> The BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline.</p> <p><strong>Results:</strong> The BCS (median: 12; IQR:11–14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50–59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50–59, and 33% (95%CI, 29-37%) among those aged >59.</p> <p><strong>Discussion:</strong> The BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide.</p> |
spellingShingle | Singh, SD Oreskovic, T Carr, S Papier, K Conroy, M Senff, JR Chemali, Z Gutierrez-Martinez, L Parodi, L Mayerhofer, E Marini, S Nunley, C Newhouse, A Ouyang, A Brouwers, HB Westover, B Rivier, C Falcone, G Howard, V Howard, G Pikula, A Ibrahim, S Sheth, KN Yechoor, N Lazar, RM Anderson, CD Tanzi, RE Fricchione, G Littlejohns, T Rosand, J The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title_full | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title_fullStr | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title_full_unstemmed | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title_short | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
title_sort | predictive validity of a brain care score for dementia and stroke data from the uk biobank cohort |
work_keys_str_mv | AT singhsd thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT oreskovict thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT carrs thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT papierk thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT conroym thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT senffjr thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT chemaliz thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT gutierrezmartinezl thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT parodil thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT mayerhofere thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT marinis thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nunleyc thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT newhousea thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT ouyanga thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT brouwershb thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT westoverb thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT rivierc thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT falconeg thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT howardv thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT howardg thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT pikulaa thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT ibrahims thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT shethkn thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT yechoorn thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT lazarrm thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT andersoncd thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT tanzire thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT fricchioneg thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT littlejohnst thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT rosandj thepredictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT singhsd predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT oreskovict predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT carrs predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT papierk predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT conroym predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT senffjr predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT chemaliz predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT gutierrezmartinezl predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT parodil predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT mayerhofere predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT marinis predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nunleyc predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT newhousea predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT ouyanga predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT brouwershb predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT westoverb predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT rivierc predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT falconeg predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT howardv predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT howardg predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT pikulaa predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT ibrahims predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT shethkn predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT yechoorn predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT lazarrm predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT andersoncd predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT tanzire predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT fricchioneg predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT littlejohnst predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT rosandj predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort |