Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta.
Obesity per se is a recognized risk factor for cardiovascular disease exerting independent adverse effects on the cardiovascular system. Despite this well documented link, the mechanisms by which obesity modulates cardiovascular risk are not well understood. Obesity is linked to a wide variety of ca...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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S. Karger AG
2014
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| _version_ | 1826271689303916544 |
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| author | Rider, O Lewis, A Neubauer, S |
| author_facet | Rider, O Lewis, A Neubauer, S |
| author_sort | Rider, O |
| collection | OXFORD |
| description | Obesity per se is a recognized risk factor for cardiovascular disease exerting independent adverse effects on the cardiovascular system. Despite this well documented link, the mechanisms by which obesity modulates cardiovascular risk are not well understood. Obesity is linked to a wide variety of cardiac changes, from subclinical diastolic dysfunction to end stage systolic heart failure. In addition, obesity causes changes in cardiac metabolism that make ATP production and utilization less efficient producing functional consequences that are linked to the increased rate of heart failure in this population. This review focuses on the cardiovascular structural and metabolic remodelling that occurs in obesity with and without co-morbidities and the potential links to increased mortality in this population. © 2014 S. Karger GmbH, Freiburg. |
| first_indexed | 2024-03-06T22:00:38Z |
| format | Journal article |
| id | oxford-uuid:4e7954d6-8b37-4481-9f30-83aea8a483bc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:00:38Z |
| publishDate | 2014 |
| publisher | S. Karger AG |
| record_format | dspace |
| spelling | oxford-uuid:4e7954d6-8b37-4481-9f30-83aea8a483bc2022-03-26T16:01:21ZStructural and Metabolic Effects of Obesity on the Myocardium and the Aorta.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e7954d6-8b37-4481-9f30-83aea8a483bcEnglishSymplectic Elements at OxfordS. Karger AG2014Rider, OLewis, ANeubauer, SObesity per se is a recognized risk factor for cardiovascular disease exerting independent adverse effects on the cardiovascular system. Despite this well documented link, the mechanisms by which obesity modulates cardiovascular risk are not well understood. Obesity is linked to a wide variety of cardiac changes, from subclinical diastolic dysfunction to end stage systolic heart failure. In addition, obesity causes changes in cardiac metabolism that make ATP production and utilization less efficient producing functional consequences that are linked to the increased rate of heart failure in this population. This review focuses on the cardiovascular structural and metabolic remodelling that occurs in obesity with and without co-morbidities and the potential links to increased mortality in this population. © 2014 S. Karger GmbH, Freiburg. |
| spellingShingle | Rider, O Lewis, A Neubauer, S Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title | Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title_full | Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title_fullStr | Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title_full_unstemmed | Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title_short | Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. |
| title_sort | structural and metabolic effects of obesity on the myocardium and the aorta |
| work_keys_str_mv | AT ridero structuralandmetaboliceffectsofobesityonthemyocardiumandtheaorta AT lewisa structuralandmetaboliceffectsofobesityonthemyocardiumandtheaorta AT neubauers structuralandmetaboliceffectsofobesityonthemyocardiumandtheaorta |