A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.

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Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that...

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Bibliographic Details
Main Authors: Dejnirattisai, W, Wongwiwat, W, Supasa, S, Zhang, X, Dai, X, Rouvinsky, A, Jumnainsong, A, Edwards, C, Quyen, N, Duangchinda, T, Grimes, J, Tsai, W, Lai, C, Wang, W, Malasit, P, Farrar, J, Simmons, C, Zhou, Z, Rey, F, Mongkolsapaya, J, Screaton, G
Format: Journal article
Language:English
Published: Nature Publishing Group 2014

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