Induction and amelioration of environmental stress in isolated islets until transplantation
Pancreatic tissue, processed for subsequent clinical islet transplantation, is exposed to enormous biophysical and biochemical stress causing injury and death in a large number of islets even before they are transplanted. Since several steps within this heterogenous process are associated with non-p...
| मुख्य लेखकों: | , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2006
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| _version_ | 1826271715882172416 |
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| author | Brandhorst, D Brandhorst, H Linn, T |
| author_facet | Brandhorst, D Brandhorst, H Linn, T |
| author_sort | Brandhorst, D |
| collection | OXFORD |
| description | Pancreatic tissue, processed for subsequent clinical islet transplantation, is exposed to enormous biophysical and biochemical stress causing injury and death in a large number of islets even before they are transplanted. Since several steps within this heterogenous process are associated with non-physiologic and harmful ambient conditions the damaging mechanisms are attributed to four different determinants: 1) brain death in the organ donor, 2) insufficient oxygen supply during pancreas procurement, isolation processing, culture and after intraportal transplantation, 3) destruction of the natural environment during isolation, and 4) exposure to toxic reagents during the isolation process. Potential strategies to ameliorate the detrimental impact of these factors on the quality of subsequently transplanted islets are discussed. © 2006 Bentham Science Publishers Ltd. |
| first_indexed | 2024-03-06T22:01:03Z |
| format | Journal article |
| id | oxford-uuid:4e9996d6-6848-4bf7-a313-55d9326b3fbb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:01:03Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:4e9996d6-6848-4bf7-a313-55d9326b3fbb2022-03-26T16:02:04ZInduction and amelioration of environmental stress in isolated islets until transplantationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4e9996d6-6848-4bf7-a313-55d9326b3fbbEnglishSymplectic Elements at Oxford2006Brandhorst, DBrandhorst, HLinn, TPancreatic tissue, processed for subsequent clinical islet transplantation, is exposed to enormous biophysical and biochemical stress causing injury and death in a large number of islets even before they are transplanted. Since several steps within this heterogenous process are associated with non-physiologic and harmful ambient conditions the damaging mechanisms are attributed to four different determinants: 1) brain death in the organ donor, 2) insufficient oxygen supply during pancreas procurement, isolation processing, culture and after intraportal transplantation, 3) destruction of the natural environment during isolation, and 4) exposure to toxic reagents during the isolation process. Potential strategies to ameliorate the detrimental impact of these factors on the quality of subsequently transplanted islets are discussed. © 2006 Bentham Science Publishers Ltd. |
| spellingShingle | Brandhorst, D Brandhorst, H Linn, T Induction and amelioration of environmental stress in isolated islets until transplantation |
| title | Induction and amelioration of environmental stress in isolated islets until transplantation |
| title_full | Induction and amelioration of environmental stress in isolated islets until transplantation |
| title_fullStr | Induction and amelioration of environmental stress in isolated islets until transplantation |
| title_full_unstemmed | Induction and amelioration of environmental stress in isolated islets until transplantation |
| title_short | Induction and amelioration of environmental stress in isolated islets until transplantation |
| title_sort | induction and amelioration of environmental stress in isolated islets until transplantation |
| work_keys_str_mv | AT brandhorstd inductionandameliorationofenvironmentalstressinisolatedisletsuntiltransplantation AT brandhorsth inductionandameliorationofenvironmentalstressinisolatedisletsuntiltransplantation AT linnt inductionandameliorationofenvironmentalstressinisolatedisletsuntiltransplantation |