Induction and amelioration of environmental stress in isolated islets until transplantation

Induction and amelioration of environmental stress in isolated islets until transplantation

Pancreatic tissue, processed for subsequent clinical islet transplantation, is exposed to enormous biophysical and biochemical stress causing injury and death in a large number of islets even before they are transplanted. Since several steps within this heterogenous process are associated with non-p...

Descripció completa

Dades bibliogràfiques
Autors principals:	Brandhorst, D, Brandhorst, H, Linn, T
Format:	Journal article
Idioma:	English
Publicat:	2006

Ítems similars

Pancreatic islets: methods for isolation and purification of juvenile and adult pig islets
per: Brandhorst, H, et al.
Publicat: (2016)

Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.
per: Brandhorst, D, et al.
Publicat: (2000)

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
per: Linn, T, et al.
Publicat: (2006)

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
per: Brandhorst, D, et al.
Publicat: (2006)

Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation
per: Brandhorst, H, et al.
Publicat: (2023)

Enzyme development for human islet isolation: Five decades of progress or stagnation?
per: Brandhorst, D, et al.
Publicat: (2017)

Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
per: Brandhorst, D, et al.
Publicat: (2001)

Does islet size really influence graft function following clinical islet transplantation?
per: Hughes, S, et al.
Publicat: (2018)

Influence of neutral protease activity on human islet isolation outcome.
per: Brandhorst, H, et al.
Publicat: (2005)

Islet cell transplantation - Current state and perspectives
per: Brendel, MD, et al.
Publicat: (2003)

Successful human islet isolation utilizing recombinant collagenase.
per: Brandhorst, H, et al.
Publicat: (2003)

High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
per: Brandhorst, D, et al.
Publicat: (2002)

Erratum: Vitacyte collagenase HA: A novel enzyme blend for efficient human islet isolation (Transplantation (2009) 88 (1400))
per: Caballero-Corbalán, J, et al.
Publicat: (2010)

Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation
per: Brandhorst, H, et al.
Publicat: (2018)

Evaluation of perfluorohexyloctane/polydimethylsiloxane for pancreas preservation for clinical islet isolation and transplantation
per: Sthle, M, et al.
Publicat: (2016)

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
per: Brandhorst, D, et al.
Publicat: (2022)

Strategies to improve the oxygen supply to microencapsulated islets
per: Brandhorst, D, et al.
Publicat: (2019)

Comparison of neutral proteases and collagenase class I as essential enzymes for human islet isolation
per: Brandhorst, H, et al.
Publicat: (2015)

Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
per: Iken, M, et al.
Publicat: (2009)

High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets
per: Brandhorst, D, et al.
Publicat: (2016)

Can the density of native pancreatic tissue slices predict human islet isolation and purification outcome?
per: Eckhard, M, et al.
Publicat: (2004)

Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
per: Brandhorst, D, et al.
Publicat: (2005)

Experience with human islet transplantation in Sweden.
per: Tibell, A, et al.
Publicat: (2001)

Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.
per: Brandhorst, H, et al.
Publicat: (2009)

Islet transplantation: present clinical situation and future aspects.
per: Bretzel, R, et al.
Publicat: (2001)

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
per: Brandhorst, D, et al.
Publicat: (2013)

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets
per: Brandhorst, D, et al.
Publicat: (2013)

Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
per: Brandhorst, D, et al.
Publicat: (2005)

Isolation of adult porcine islets of Langerhans.
per: Toso, C, et al.
Publicat: (2000)

Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
per: Brandhorst, D, et al.
Publicat: (2021)

Pretreatment of isolated islets with caspase-3 inhibitor DEVD increases graft survival after xenotransplantation.
per: Brandhorst, H, et al.
Publicat: (2003)

Effect of etanercept concentration on human islet integrity
per: Acreman, S, et al.
Publicat: (2017)

Adjustment of the ratio between collagenase class II and I improves islet isolation outcome.
per: Brandhorst, D, et al.
Publicat: (2005)

Optimization in osmolality and range of density of a continuous ficoll-sodium-diatrizoate gradient for isopycnic purification of isolated human islets.
per: Eckhard, M, et al.
Publicat: (2004)

Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.
per: Brandhorst, D, et al.
Publicat: (2005)

Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine.
per: Kakabadze, Z, et al.
Publicat: (2011)

Quantifying the effects of different neutral proteases on human islet integrity
per: Brandhorst, H, et al.
Publicat: (2018)

No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation.
per: Caballero-Corbalán, J, et al.
Publicat: (2007)

Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
per: Brandhorst, D, et al.
Publicat: (2005)

New class of oxygen carriers improves islet isolation from long-term stored rat pancreata.
per: Brandhorst, H, et al.
Publicat: (2008)