Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects

The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is...

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Bibliographic Details
Main Authors: Bard-Chapeau, E, Szumska, D, Jacob, B, Chua, B, Chatterjee, G, Zhang, Y, Ward, J, Urun, F, Kinameri, E, Vincent, S, Ahmed, S, Bhattacharya, S, Osato, M, Perkins, A, Moore, A, Jenkins, N, Copeland, N
Format: Journal article
Language:English
Published: Public Library of Science 2014

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