A triply divergent reagent for glycoprotein synthesis
Chemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one-step diversification of a GlcNAc-ylating re...
| Hlavní autoři: | , , |
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| Médium: | Journal article |
| Vydáno: |
Wiley
2015
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| _version_ | 1826271748391174144 |
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| author | De Munari, S Schiffner, T Davis, B |
| author_facet | De Munari, S Schiffner, T Davis, B |
| author_sort | De Munari, S |
| collection | OXFORD |
| description | Chemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one-step diversification of a GlcNAc-ylating reagent and its application in both site-specific and non-site-specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds. |
| first_indexed | 2024-03-06T22:01:35Z |
| format | Journal article |
| id | oxford-uuid:4ec74b00-a76d-4b2e-9740-511c4d2b37e3 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:01:35Z |
| publishDate | 2015 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:4ec74b00-a76d-4b2e-9740-511c4d2b37e32022-03-26T16:03:09ZA triply divergent reagent for glycoprotein synthesisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4ec74b00-a76d-4b2e-9740-511c4d2b37e3Symplectic Elements at OxfordWiley2015De Munari, SSchiffner, TDavis, BChemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one-step diversification of a GlcNAc-ylating reagent and its application in both site-specific and non-site-specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds. |
| spellingShingle | De Munari, S Schiffner, T Davis, B A triply divergent reagent for glycoprotein synthesis |
| title | A triply divergent reagent for glycoprotein synthesis |
| title_full | A triply divergent reagent for glycoprotein synthesis |
| title_fullStr | A triply divergent reagent for glycoprotein synthesis |
| title_full_unstemmed | A triply divergent reagent for glycoprotein synthesis |
| title_short | A triply divergent reagent for glycoprotein synthesis |
| title_sort | triply divergent reagent for glycoprotein synthesis |
| work_keys_str_mv | AT demunaris atriplydivergentreagentforglycoproteinsynthesis AT schiffnert atriplydivergentreagentforglycoproteinsynthesis AT davisb atriplydivergentreagentforglycoproteinsynthesis AT demunaris triplydivergentreagentforglycoproteinsynthesis AT schiffnert triplydivergentreagentforglycoproteinsynthesis AT davisb triplydivergentreagentforglycoproteinsynthesis |