Quiescence as a mechanism for cyclical hypoxia and acidosis
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur thro...
| Main Authors: | , , , |
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| Format: | Journal article |
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2007
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| _version_ | 1797067808905887744 |
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| author | Smallbone, K Gavaghan, D Maini, P Brady, J |
| author_facet | Smallbone, K Gavaghan, D Maini, P Brady, J |
| author_sort | Smallbone, K |
| collection | OXFORD |
| description | Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur through oscillations in the h ae modynamics of nearby and distant blood vessels. In this paper we examine an alternative hypothesis, that cycles of metabolite concentrations are also driven by cycles of cellular quiescence and proliferation. Using a mathemat |
| first_indexed | 2024-03-06T22:01:40Z |
| format | Journal article |
| id | oxford-uuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd5 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:01:40Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd52022-03-26T16:03:18ZQuiescence as a mechanism for cyclical hypoxia and acidosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd5Department of Computer Science2007Smallbone, KGavaghan, DMaini, PBrady, JTumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur through oscillations in the h ae modynamics of nearby and distant blood vessels. In this paper we examine an alternative hypothesis, that cycles of metabolite concentrations are also driven by cycles of cellular quiescence and proliferation. Using a mathemat |
| spellingShingle | Smallbone, K Gavaghan, D Maini, P Brady, J Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title | Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title_full | Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title_fullStr | Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title_full_unstemmed | Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title_short | Quiescence as a mechanism for cyclical hypoxia and acidosis |
| title_sort | quiescence as a mechanism for cyclical hypoxia and acidosis |
| work_keys_str_mv | AT smallbonek quiescenceasamechanismforcyclicalhypoxiaandacidosis AT gavaghand quiescenceasamechanismforcyclicalhypoxiaandacidosis AT mainip quiescenceasamechanismforcyclicalhypoxiaandacidosis AT bradyj quiescenceasamechanismforcyclicalhypoxiaandacidosis |