Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases
<p><strong>Background: </strong>The northwestern border of Thailand is an area of low seasonal malaria transmission. Until recent successful malaria elimination activities, malaria was a major cause of disease and death. Historically the incidences of symptomatic ...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2023
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| _version_ | 1826311102672142336 |
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| author | Chu, CS Stolbrink, M Stolady, D Saito, M Beau, C Choun, K Wah, TG Mu, N Htoo, K Nu, B Keereevijit, A Wiladpaingern, J Carrara, V Phyo, AP Lwin, KM Luxemburger, C Proux, S Charunwatthana, P McGready, R White, NJ Nosten, F |
| author_facet | Chu, CS Stolbrink, M Stolady, D Saito, M Beau, C Choun, K Wah, TG Mu, N Htoo, K Nu, B Keereevijit, A Wiladpaingern, J Carrara, V Phyo, AP Lwin, KM Luxemburger, C Proux, S Charunwatthana, P McGready, R White, NJ Nosten, F |
| author_sort | Chu, CS |
| collection | OXFORD |
| description | <p><strong>Background: </strong>The northwestern border of Thailand is an area of low seasonal malaria transmission. Until recent successful malaria elimination activities, malaria was a major cause of disease and death. Historically the incidences of symptomatic <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> malaria were approximately similar.</p>
<p><strong>Methods: </strong>All malaria cases managed in the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016 were reviewed.</p>
<p><strong>Results: </strong>There were 80 841 consultations for symptomatic <em>P. vivax</em> and 94 467 for symptomatic <em>P. falciparum</em> malaria. Overall, 4844 (5.1%) patients with <em>P. falciparum</em> malaria were admitted to field hospitals, of whom 66 died, compared with 278 (0.34%) with <em>P. vivax</em> malaria, of whom 4 died (3 had diagnoses of sepsis, so the contribution of malaria to their fatal outcomes is uncertain). Applying the 2015 World Health Organization severe malaria criteria, 68 of 80 841 <em>P. vivax</em> admissions (0.08%) and 1482 of 94 467 <em>P. falciparum</em> admissions (1.6%) were classified as severe. Overall, patients with <em>P. falciparum</em> malaria were 15 (95% confidence interval, 13.2–16.8) times more likely than those with <em>P. vivax</em> malaria to require hospital admission, 19 (14.6–23.8) times more likely to develop severe malaria, and ≥14 (5.1–38.7) times more likely to die.</p>
<p><strong>Conclusions: </strong>In this area, both <em>P. falciparum</em> and <em>P. vivax</em> infections were important causes of hospitalization, but life-threatening <em>P. vivax</em> illness was rare.</p> |
| first_indexed | 2024-03-07T08:03:25Z |
| format | Journal article |
| id | oxford-uuid:4edbecfe-2e43-4728-a2a4-26efb7da5dbd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:03:25Z |
| publishDate | 2023 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:4edbecfe-2e43-4728-a2a4-26efb7da5dbd2023-10-19T11:41:29ZSevere falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 casesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4edbecfe-2e43-4728-a2a4-26efb7da5dbdEnglishSymplectic ElementsOxford University Press2023Chu, CSStolbrink, MStolady, DSaito, MBeau, CChoun, KWah, TGMu, NHtoo, KNu, BKeereevijit, AWiladpaingern, JCarrara, VPhyo, APLwin, KMLuxemburger, CProux, SCharunwatthana, PMcGready, RWhite, NJNosten, F<p><strong>Background: </strong>The northwestern border of Thailand is an area of low seasonal malaria transmission. Until recent successful malaria elimination activities, malaria was a major cause of disease and death. Historically the incidences of symptomatic <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> malaria were approximately similar.</p> <p><strong>Methods: </strong>All malaria cases managed in the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016 were reviewed.</p> <p><strong>Results: </strong>There were 80 841 consultations for symptomatic <em>P. vivax</em> and 94 467 for symptomatic <em>P. falciparum</em> malaria. Overall, 4844 (5.1%) patients with <em>P. falciparum</em> malaria were admitted to field hospitals, of whom 66 died, compared with 278 (0.34%) with <em>P. vivax</em> malaria, of whom 4 died (3 had diagnoses of sepsis, so the contribution of malaria to their fatal outcomes is uncertain). Applying the 2015 World Health Organization severe malaria criteria, 68 of 80 841 <em>P. vivax</em> admissions (0.08%) and 1482 of 94 467 <em>P. falciparum</em> admissions (1.6%) were classified as severe. Overall, patients with <em>P. falciparum</em> malaria were 15 (95% confidence interval, 13.2–16.8) times more likely than those with <em>P. vivax</em> malaria to require hospital admission, 19 (14.6–23.8) times more likely to develop severe malaria, and ≥14 (5.1–38.7) times more likely to die.</p> <p><strong>Conclusions: </strong>In this area, both <em>P. falciparum</em> and <em>P. vivax</em> infections were important causes of hospitalization, but life-threatening <em>P. vivax</em> illness was rare.</p> |
| spellingShingle | Chu, CS Stolbrink, M Stolady, D Saito, M Beau, C Choun, K Wah, TG Mu, N Htoo, K Nu, B Keereevijit, A Wiladpaingern, J Carrara, V Phyo, AP Lwin, KM Luxemburger, C Proux, S Charunwatthana, P McGready, R White, NJ Nosten, F Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title | Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title_full | Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title_fullStr | Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title_full_unstemmed | Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title_short | Severe falciparum and vivax malaria on the Thailand-Myanmar border: a review of 1503 cases |
| title_sort | severe falciparum and vivax malaria on the thailand myanmar border a review of 1503 cases |
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