Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis

Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis

Human IgG Fc glycosylation modulates immunological effector functions such as antibody-dependent cellular cytotoxicity and phagocytosis. Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal antibodies. The N-linked glycans of Fc are typically complex-ty...

Bibliografiset tiedot
Päätekijät:	Bowden, T, Baruah, K, Coles, C, Harvey, D, Yu, X, Song, B, Stuart, D, Aricescu, A, Scanlan, C, Jones, E, Crispin, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	American Chemical Society 2012

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