Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis

Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis

Human IgG Fc glycosylation modulates immunological effector functions such as antibody-dependent cellular cytotoxicity and phagocytosis. Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal antibodies. The N-linked glycans of Fc are typically complex-ty...

Bibliográfalaš dieđut
Váldodahkkit:	Bowden, T, Baruah, K, Coles, C, Harvey, D, Yu, X, Song, B, Stuart, D, Aricescu, A, Scanlan, C, Jones, E, Crispin, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	American Chemical Society 2012

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