Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England
The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohor...
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Springer Nature
2024
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| _version_ | 1826312849092247552 |
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| author | Ward, IL Robertson, C Agrawal, U Patterson, L Bradley, DT Shi, T de Lusignan, S Hobbs, FDR Sheikh, A Nafilyan, V |
| author_facet | Ward, IL Robertson, C Agrawal, U Patterson, L Bradley, DT Shi, T de Lusignan, S Hobbs, FDR Sheikh, A Nafilyan, V |
| author_sort | Ward, IL |
| collection | OXFORD |
| description | The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from the 2021 Census linked to electronic health records. We fitted cause-specific Cox models to examine the association between health conditions and the risk of COVID-19 death and all-other-cause death for adults aged 50-100-years in England vaccinated with a booster in autumn 2022. Here we show, having learning disabilities or Down Syndrome (hazard ratio=5.07;95% confidence interval=3.69-6.98), pulmonary hypertension or fibrosis (2.88;2.43-3.40), motor neuron disease, multiple sclerosis, myasthenia or Huntington’s disease (2.94, 1.82-4.74), cancer of blood and bone marrow (3.11;2.72-3.56), Parkinson’s disease (2.74;2.34-3.20), lung or oral cancer (2.57;2.04 to 3.24), dementia (2.64;2.46 to 2.83) or liver cirrhosis (2.65;1.95 to 3.59) was associated with an increased risk of COVID-19 death. Individuals with cancer of the blood or bone marrow, chronic kidney disease, cystic fibrosis, pulmonary hypotension or fibrosis, or rheumatoid arthritis or systemic lupus erythematosus had a significantly higher risk of COVID-19 death relative to other causes of death compared with individuals who did not have diagnoses. Policy makers should continue to priorities vulnerable groups for subsequent COVID-19 booster doses to minimise the risk of COVID-19 death. |
| first_indexed | 2024-09-25T04:01:34Z |
| format | Journal article |
| id | oxford-uuid:4f546d74-373f-4a09-a3cf-5ccd4927cec5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:01:34Z |
| publishDate | 2024 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:4f546d74-373f-4a09-a3cf-5ccd4927cec52024-04-30T10:25:29ZRisk of COVID-19 death in adults who received booster COVID-19 vaccinations in EnglandJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4f546d74-373f-4a09-a3cf-5ccd4927cec5EnglishSymplectic ElementsSpringer Nature2024Ward, ILRobertson, CAgrawal, UPatterson, LBradley, DTShi, Tde Lusignan, SHobbs, FDRSheikh, ANafilyan, VThe emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities. We undertook a national retrospective cohort study using data from the 2021 Census linked to electronic health records. We fitted cause-specific Cox models to examine the association between health conditions and the risk of COVID-19 death and all-other-cause death for adults aged 50-100-years in England vaccinated with a booster in autumn 2022. Here we show, having learning disabilities or Down Syndrome (hazard ratio=5.07;95% confidence interval=3.69-6.98), pulmonary hypertension or fibrosis (2.88;2.43-3.40), motor neuron disease, multiple sclerosis, myasthenia or Huntington’s disease (2.94, 1.82-4.74), cancer of blood and bone marrow (3.11;2.72-3.56), Parkinson’s disease (2.74;2.34-3.20), lung or oral cancer (2.57;2.04 to 3.24), dementia (2.64;2.46 to 2.83) or liver cirrhosis (2.65;1.95 to 3.59) was associated with an increased risk of COVID-19 death. Individuals with cancer of the blood or bone marrow, chronic kidney disease, cystic fibrosis, pulmonary hypotension or fibrosis, or rheumatoid arthritis or systemic lupus erythematosus had a significantly higher risk of COVID-19 death relative to other causes of death compared with individuals who did not have diagnoses. Policy makers should continue to priorities vulnerable groups for subsequent COVID-19 booster doses to minimise the risk of COVID-19 death. |
| spellingShingle | Ward, IL Robertson, C Agrawal, U Patterson, L Bradley, DT Shi, T de Lusignan, S Hobbs, FDR Sheikh, A Nafilyan, V Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title | Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title_full | Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title_fullStr | Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title_full_unstemmed | Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title_short | Risk of COVID-19 death in adults who received booster COVID-19 vaccinations in England |
| title_sort | risk of covid 19 death in adults who received booster covid 19 vaccinations in england |
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