Expanding the epigenetic landscape: novel modifications of cytosine in genomic DNA.
Methylation of the base cytosine in DNA is critical for silencing endogenous retroviruses, regulating gene expression, and establishing cellular identity, and has long been regarded as an indelible epigenetic mark. The recent discovery that the ten eleven translocation (TET) proteins can oxidize 5-m...
| Main Authors: | , |
|---|---|
| 格式: | Journal article |
| 语言: | English |
| 出版: |
Cold Spring Harbor Laboratory Press
2014
|