Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven from cytokine-induced activation
The Thrombopoietin Receptor (TpoR) is a central player in Myeloproliferative Neoplasms (MPNs). Mutations in JAK2, calreticulin or in TpoR itself drive constitutive activation of TpoR and uncontrolled proliferation and differentiation of hematopoietic stem cells and progenitors. The JAK2 V617F mutati...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Society of Hematology
2023
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