Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles.
The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loadin...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Royal Society of Chemistry
2016
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| _version_ | 1797067935344230400 |
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| author | Heuer-Jungemann, A El-Sagheer, A Lackie, P Brown, T Kanaras, A |
| author_facet | Heuer-Jungemann, A El-Sagheer, A Lackie, P Brown, T Kanaras, A |
| author_sort | Heuer-Jungemann, A |
| collection | OXFORD |
| description | The design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target. |
| first_indexed | 2024-03-06T22:03:31Z |
| format | Journal article |
| id | oxford-uuid:4f64034d-f9da-4d62-96f1-b107c0db6162 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:03:31Z |
| publishDate | 2016 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:4f64034d-f9da-4d62-96f1-b107c0db61622022-03-26T16:06:53ZSelective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4f64034d-f9da-4d62-96f1-b107c0db6162EnglishSymplectic Elements at OxfordRoyal Society of Chemistry2016Heuer-Jungemann, AEl-Sagheer, ALackie, PBrown, TKanaras, AThe design of nanoparticles that can selectively perform multiple roles is of utmost importance for the development of the next generation of nanoparticulate drug delivery systems. So far most research studies are focused on the customization of nanoparticulate carriers to maximize their drug loading, enhance their optical signature for tracking in cells or provide photo-responsive effects for therapeutic purposes. However, a vital requirement of the new generation of drug carriers must be the ability to deliver their payload selectively only to cells of interest rather than the majority of various cells in the vicinity. Here we show for the first time a new design of nanoparticulate drug carriers that can specifically distinguish different cell types based on their mRNA signature. These nanoparticles sense and efficiently kill model tumour cells by the delivery of an anti-cancer drug but retain their payload in cells lacking the specific mRNA target. |
| spellingShingle | Heuer-Jungemann, A El-Sagheer, A Lackie, P Brown, T Kanaras, A Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title | Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title_full | Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title_fullStr | Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title_full_unstemmed | Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title_short | Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. |
| title_sort | selective killing of cells triggered by their mrna signature in the presence of smart nanoparticles |
| work_keys_str_mv | AT heuerjungemanna selectivekillingofcellstriggeredbytheirmrnasignatureinthepresenceofsmartnanoparticles AT elsagheera selectivekillingofcellstriggeredbytheirmrnasignatureinthepresenceofsmartnanoparticles AT lackiep selectivekillingofcellstriggeredbytheirmrnasignatureinthepresenceofsmartnanoparticles AT brownt selectivekillingofcellstriggeredbytheirmrnasignatureinthepresenceofsmartnanoparticles AT kanarasa selectivekillingofcellstriggeredbytheirmrnasignatureinthepresenceofsmartnanoparticles |