Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy

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Activation of invariant CD1d-dependent NKT cells (iNKT cells) in vivo through administration of the glycolipid ligand α-galactosylceramide (α-GalCer) or the sphingosine-truncated α-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and γ interferon...

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Bibliographic Details
Main Authors: Silk, J, Hermans, I, Gileadi, U, Chong, T, Shepherd, D, Salio, M, Mathew, B, Schmidt, R, Lunt, S, Williams, K, Stratford, I, Harris, A, Cerundolo, V
Format: Journal article
Language:English
Published: 2004

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