Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1

Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, MIM), a member of the IMD-family of p...

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Hlavní autoři: Dawson, J, Bruche, S, Spence, H, Braga, V, Machesky, L
Médium: Journal article
Jazyk:English
Vydáno: Public Library of Science 2012