Yeast Sen1 helicase protects the genome from transcription-associated instability

Yeast Sen1 helicase protects the genome from transcription-associated instability

Show other versions (1)

Sen1 of S.cerevisiae is a known component of the NRD complex implicated in transcription termination on nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses a wider function by restricting the occurrence of RNA:DNA hybrids that may...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Mischo, H, Gómez-González, B, Grzechnik, P, Rondón, A, Wei, W, Steinmetz, L, Aguilera, A, Proudfoot, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Elsevier 2011
Pynciau:	Pathology

Eitemau Tebyg

Yeast Sen1 helicase protects the genome from transcription-associated instability.
gan: Mischo, H, et al.
Cyhoeddwyd: (2011)

Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'.
gan: Rondon, A, et al.
Cyhoeddwyd: (2008)

Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination.
gan: Kawauchi, J, et al.
Cyhoeddwyd: (2008)

Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.
gan: Mischo, H, et al.
Cyhoeddwyd: (2013)

Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage
gan: Grzechnik, P, et al.
Cyhoeddwyd: (2018)

Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
gan: S. Wang, et al.
Cyhoeddwyd: (2019-04-01)

ATPase site architecture and helicase mechanism of an archaeal MCM
gan: Moreau, M, et al.
Cyhoeddwyd: (2007)

Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage
gan: Pawel Grzechnik, et al.
Cyhoeddwyd: (2018-05-01)

Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae.
gan: Rondón, A, et al.
Cyhoeddwyd: (2009)

Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination
gan: West, S, et al.
Cyhoeddwyd: (2008)

Cell-cycle modulation of transcription termination factor Sen1
gan: Mischo, H, et al.
Cyhoeddwyd: (2018)

The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts.
gan: Simona Cugusi, et al.
Cyhoeddwyd: (2016-01-01)

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
gan: Newman, JA, et al.
Cyhoeddwyd: (2020)

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
gan: María S Domínguez-Sánchez, et al.
Cyhoeddwyd: (2011-12-01)

Aneuploidy Drives Genomic Instability in Yeast
gan: Sheltzer, Jason Meyer, et al.
Cyhoeddwyd: (2013)

Definition of transcriptional pause elements in fission yeast.
gan: Aranda, A, et al.
Cyhoeddwyd: (1999)

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
gan: Bassam Abu-Libdeh, et al.
Cyhoeddwyd: (2022-03-01)

Terminate and make a loop: regulation of transcriptional directionality
gan: Tan-Wong, S, et al.
Cyhoeddwyd: (2014)

Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei
gan: Jackson, D, et al.
Cyhoeddwyd: (1998)

DNA repair and genomic instability in yeast aging
gan: Park, Peter Unnam, 1971-
Cyhoeddwyd: (2005)

Gene loops enhance transcriptional directionality
gan: Tan-Wong, S, et al.
Cyhoeddwyd: (2012)

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.
gan: Juan Lafuente-Barquero, et al.
Cyhoeddwyd: (2017-12-01)

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
gan: Phong Lan Thao Tran, et al.
Cyhoeddwyd: (2017-04-01)

Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia
gan: Chi Keung Cheng, et al.
Cyhoeddwyd: (2016-04-01)

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.
gan: Gullerova, M, et al.
Cyhoeddwyd: (2012)

Rad25p, a DNA helicase subunit of yeast transcription factor TFIIH, is required for promoter escape in vivo.
gan: Ostapenko, D, et al.
Cyhoeddwyd: (2000)

Transcriptional collision between convergent genes in budding yeast.
gan: Prescott, E, et al.
Cyhoeddwyd: (2002)

The transcription cycle of RNA polymerase II in living cells
gan: Kimura, H, et al.
Cyhoeddwyd: (2002)

Similar active genes cluster in specialized transcription factories
gan: Xu, M, et al.
Cyhoeddwyd: (2008)

Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability
gan: Lorn Kategaya, et al.
Cyhoeddwyd: (2019-03-01)

Genomic disorders : [electronic resource] : the genomic basis of disease /
gan: 190983 Lupski, James R., et al.
Cyhoeddwyd: (2006)

Transcriptional interference and gene orientation in yeast: noncoding RNA connections.
gan: Gullerova, M, et al.
Cyhoeddwyd: (2010)

Heat shock drives genomic instability and phenotypic variations in yeast
gan: Li Shen, et al.
Cyhoeddwyd: (2020-08-01)

Genomic Instability and Cellular Senescence: Lessons From the Budding Yeast
gan: Jee Whu Lee, et al.
Cyhoeddwyd: (2021-01-01)

Patterns of Genomic Instability in Interspecific Yeast Hybrids With Diverse Ancestries
gan: Devin P. Bendixsen, et al.
Cyhoeddwyd: (2021-10-01)

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
gan: Simone Lieb, et al.
Cyhoeddwyd: (2019-03-01)

Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.
gan: Moreira, M, et al.
Cyhoeddwyd: (2004)

Transcriptional termination signals for RNA polymerase II in fission yeast.
gan: Birse, C, et al.
Cyhoeddwyd: (1997)

Targeting werner helicase with synthetic lethality in microsatellite instability cancers: Promising therapeutic approaches
gan: Huanzhang Xie, et al.
Cyhoeddwyd: (2024-06-01)

Coupling termination of transcription to messenger RNA maturation in yeast.
gan: Birse, C, et al.
Cyhoeddwyd: (1998)