Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study.
OBJECTIVE: The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: The prospective European Prospective Inv...
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| Materiálatiipa: | Journal article |
| Giella: | English |
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American Diabetes Association Inc.
2014
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| _version_ | 1826271907313352704 |
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| author | van Nielen, M Feskens, E Mensink, M Sluijs, I Molina, E Amiano, P Ardanaz, E Balkau, B Beulens, J Boeing, H Clavel-Chapelon, F Fagherazzi, G Franks, P Halkjaer, J Huerta, J Katzke, V Key, T Khaw, K Krogh, V Kühn, T Menéndez, V Nilsson, P Overvad, K Palli, D Panico, S |
| author_facet | van Nielen, M Feskens, E Mensink, M Sluijs, I Molina, E Amiano, P Ardanaz, E Balkau, B Beulens, J Boeing, H Clavel-Chapelon, F Fagherazzi, G Franks, P Halkjaer, J Huerta, J Katzke, V Key, T Khaw, K Krogh, V Kühn, T Menéndez, V Nilsson, P Overvad, K Palli, D Panico, S |
| author_sort | van Nielen, M |
| collection | OXFORD |
| description | OBJECTIVE: The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from eight European countries, with an average follow-up time of 12.0 years. Pooled country-specific hazard ratios (HRs) and 95% CI of prentice-weighted Cox regression analyses were used to estimate type 2 diabetes incidence according to protein intake. RESULTS: After adjustment for important diabetes risk factors and dietary factors, the incidence of type 2 diabetes was higher in those with high intake of total protein (per 10 g: HR 1.06 [95% CI 1.02-1.09], P(trend) < 0.001) and animal protein (per 10 g: 1.05 [1.02-1.08], P(trend) = 0.001). Effect modification by sex (P < 0.001) and BMI among women (P < 0.001) was observed. Compared with the overall analyses, associations were stronger in women, more specifically obese women with a BMI >30 kg/m(2) (per 10 g animal protein: 1.19 [1.09-1.32]), and nonsignificant in men. Plant protein intake was not associated with type 2 diabetes (per 10 g: 1.04 [0.93-1.16], P(trend) = 0.098). CONCLUSIONS: High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults. In view of the rapidly increasing prevalence of type 2 diabetes, limiting iso-energetic diets high in dietary proteins, particularly from animal sources, should be considered. |
| first_indexed | 2024-03-06T22:04:08Z |
| format | Journal article |
| id | oxford-uuid:4f94dd5f-7934-4f09-8c76-872cad0a230c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:04:08Z |
| publishDate | 2014 |
| publisher | American Diabetes Association Inc. |
| record_format | dspace |
| spelling | oxford-uuid:4f94dd5f-7934-4f09-8c76-872cad0a230c2022-03-26T16:08:05ZDietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4f94dd5f-7934-4f09-8c76-872cad0a230cEnglishSymplectic Elements at OxfordAmerican Diabetes Association Inc.2014van Nielen, MFeskens, EMensink, MSluijs, IMolina, EAmiano, PArdanaz, EBalkau, BBeulens, JBoeing, HClavel-Chapelon, FFagherazzi, GFranks, PHalkjaer, JHuerta, JKatzke, VKey, TKhaw, KKrogh, VKühn, TMenéndez, VNilsson, POvervad, KPalli, DPanico, SOBJECTIVE: The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from eight European countries, with an average follow-up time of 12.0 years. Pooled country-specific hazard ratios (HRs) and 95% CI of prentice-weighted Cox regression analyses were used to estimate type 2 diabetes incidence according to protein intake. RESULTS: After adjustment for important diabetes risk factors and dietary factors, the incidence of type 2 diabetes was higher in those with high intake of total protein (per 10 g: HR 1.06 [95% CI 1.02-1.09], P(trend) < 0.001) and animal protein (per 10 g: 1.05 [1.02-1.08], P(trend) = 0.001). Effect modification by sex (P < 0.001) and BMI among women (P < 0.001) was observed. Compared with the overall analyses, associations were stronger in women, more specifically obese women with a BMI >30 kg/m(2) (per 10 g animal protein: 1.19 [1.09-1.32]), and nonsignificant in men. Plant protein intake was not associated with type 2 diabetes (per 10 g: 1.04 [0.93-1.16], P(trend) = 0.098). CONCLUSIONS: High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults. In view of the rapidly increasing prevalence of type 2 diabetes, limiting iso-energetic diets high in dietary proteins, particularly from animal sources, should be considered. |
| spellingShingle | van Nielen, M Feskens, E Mensink, M Sluijs, I Molina, E Amiano, P Ardanaz, E Balkau, B Beulens, J Boeing, H Clavel-Chapelon, F Fagherazzi, G Franks, P Halkjaer, J Huerta, J Katzke, V Key, T Khaw, K Krogh, V Kühn, T Menéndez, V Nilsson, P Overvad, K Palli, D Panico, S Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title | Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title_full | Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title_fullStr | Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title_full_unstemmed | Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title_short | Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. |
| title_sort | dietary protein intake and incidence of type 2 diabetes in europe the epic interact case cohort study |
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